Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade

Rebecca Gilbert; Chris Metcalfe; William D. Fraser; Jenny Donovan; Freddie Hamdy; David E. Neal; J. Athene Lane; Richard M. Martin

doi:10.1002/ijc.27327

Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade

Rebecca Gilbert^*, Chris Metcalfe, William D. Fraser, Jenny Donovan, Freddie Hamdy, David E. Neal, J. Athene Lane, Richard M. Martin

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

60 Citations (Scopus)

Abstract

Epidemiological studies suggest that vitamin D protects against prostate cancer, although evidence is limited and inconsistent. We investigated associations of circulating total 25-hydroxyvitamin D (25(OH)D) with prostate specific antigen-detected prostate cancer in a case-control study nested within the prostate testing for cancer and treatment (ProtecT) trial. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) quantifying the association between circulating total 25(OH)D and prostate cancer. In case-only analyses, we used unconditional logistic regression to quantify associations of total 25(OH)D with stage (advanced vs. localized) and Gleason grade (high-grade (=7) vs. low-grade (

Original language	English
Pages (from-to)	1187-1196
Number of pages	10
Journal	International Journal of Cancer
Volume	131
Issue number	5
DOIs	https://doi.org/10.1002/ijc.27327
Publication status	Published - 1 Sep 2012

Structured keywords

BTC (Bristol Trials Centre)
Centre for Surgical Research

Keywords

prostate cancer
vitamin D
25-hydroxyvitamn D
VITAMIN-D STATUS
UNITED-STATES
AFRICAN-AMERICANS
SUBSEQUENT RISK
MEN
MORTALITY
1,25-DIHYDROXYVITAMIN-D
D-1-ALPHA-HYDROXYLASE
EPIDEMIOLOGY
CALCITRIOL

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title = "Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade",

abstract = "Epidemiological studies suggest that vitamin D protects against prostate cancer, although evidence is limited and inconsistent. We investigated associations of circulating total 25-hydroxyvitamin D (25(OH)D) with prostate specific antigen-detected prostate cancer in a case-control study nested within the prostate testing for cancer and treatment (ProtecT) trial. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) quantifying the association between circulating total 25(OH)D and prostate cancer. In case-only analyses, we used unconditional logistic regression to quantify associations of total 25(OH)D with stage (advanced vs. localized) and Gleason grade (high-grade (=7) vs. low-grade (",

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author = "Rebecca Gilbert and Chris Metcalfe and Fraser, {William D.} and Jenny Donovan and Freddie Hamdy and Neal, {David E.} and Lane, {J. Athene} and Martin, {Richard M.}",

year = "2012",

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doi = "10.1002/ijc.27327",

language = "English",

volume = "131",

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T1 - Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade

AU - Gilbert, Rebecca

AU - Metcalfe, Chris

AU - Fraser, William D.

AU - Donovan, Jenny

AU - Hamdy, Freddie

AU - Neal, David E.

AU - Lane, J. Athene

AU - Martin, Richard M.

PY - 2012/9/1

Y1 - 2012/9/1

N2 - Epidemiological studies suggest that vitamin D protects against prostate cancer, although evidence is limited and inconsistent. We investigated associations of circulating total 25-hydroxyvitamin D (25(OH)D) with prostate specific antigen-detected prostate cancer in a case-control study nested within the prostate testing for cancer and treatment (ProtecT) trial. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) quantifying the association between circulating total 25(OH)D and prostate cancer. In case-only analyses, we used unconditional logistic regression to quantify associations of total 25(OH)D with stage (advanced vs. localized) and Gleason grade (high-grade (=7) vs. low-grade (

AB - Epidemiological studies suggest that vitamin D protects against prostate cancer, although evidence is limited and inconsistent. We investigated associations of circulating total 25-hydroxyvitamin D (25(OH)D) with prostate specific antigen-detected prostate cancer in a case-control study nested within the prostate testing for cancer and treatment (ProtecT) trial. Conditional logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs) quantifying the association between circulating total 25(OH)D and prostate cancer. In case-only analyses, we used unconditional logistic regression to quantify associations of total 25(OH)D with stage (advanced vs. localized) and Gleason grade (high-grade (=7) vs. low-grade (

KW - prostate cancer

KW - vitamin D

KW - 25-hydroxyvitamn D

KW - VITAMIN-D STATUS

KW - UNITED-STATES

KW - AFRICAN-AMERICANS

KW - SUBSEQUENT RISK

KW - MEN

KW - MORTALITY

KW - 1,25-DIHYDROXYVITAMIN-D

KW - D-1-ALPHA-HYDROXYLASE

KW - EPIDEMIOLOGY

KW - CALCITRIOL

U2 - 10.1002/ijc.27327

DO - 10.1002/ijc.27327

M3 - Article (Academic Journal)

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VL - 131

SP - 1187

EP - 1196

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 5

ER -

Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade

Abstract

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Keywords

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