Associations of FTO and MC4R Variants with Obesity Traits in Indians and the Role of Rural/Urban Environment as a Possible Effect Modifier

A E Taylor, M N Sandeep, C S Janipalli, C Giambartolomei, D M Evans, M V Kranthi Kumar, D G Vinay, P Smitha, V Gupta, M Aruna, S Kinra, R M Sullivan, L Bowen, N J Timpson, G Davey Smith, F Dudbridge, D Prabhakaran, Y Ben-Shlomo, K S Reddy, S EbrahimG R Chandak

Research output: Contribution to journalArticle (Academic Journal)peer-review

36 Citations (Scopus)

Abstract

Few studies have investigated the association between genetic variation and obesity traits in Indian populations or the role of environmental factors as modifiers of these relationships. In the context of rapid urbanisation, resulting in significant lifestyle changes, understanding the aetiology of obesity is important. We investigated associations of FTO and MC4R variants with obesity traits in 3390 sibling pairs from four Indian cities, most of whom were discordant for current dwelling (rural or urban). The FTO variant rs9939609 predicted increased weight (0.09 Z-scores, 95% CI: 0.03, 0.15) and BMI (0.08 Z-scores, 95% CI: 0.02, 0.14). The MC4R variant rs17782313 was weakly associated with weight and hip circumference (P <.05). There was some indication that the association between FTO and weight was stronger in urban than that in rural dwellers (P for interaction = .03), but no evidence for effect modification by diet or physical activity. Further studies are needed to investigate ways in which urban environment may modify genetic risk of obesity.
Original languageEnglish
Pages (from-to)307542
JournalJournal of Obesity
Volume2011
DOIs
Publication statusPublished - 2011

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

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