Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children

Dylan M. Williams; Abigail Fraser; William D. Fraser; Elina Hyppoenen; George Davey Smith; John Deanfield; Aroon Hingorani; Naveed Sattar; Debbie A. Lawlor

doi:10.1136/heartjnl-2013-303678

Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children

Dylan M. Williams
, Abigail Fraser
, William D. Fraser
, Elina Hyppoenen
, George Davey Smith
, John Deanfield
, Aroon Hingorani
, Naveed Sattar
, Debbie A. Lawlor^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

44 Citations (Scopus)

Abstract

OBJECTIVE: Lower maternal vitamin D status in pregnancy may be associated with increased offspring cardiovascular risk in later life, but evidence for this is scant. We examined associations of maternal total 25-hydroxyvitamin D (25(OH)D) in pregnancy with offspring cardiovascular risk factors assessed in childhood and adolescence.

DESIGN: A longitudinal, prospective study.

SETTING: The study was based on data from mother-offspring pairs in the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK prospective population-based birth cohort (N=4109).

OUTCOME MEASURES: Offspring cardiovascular risk factors were measured in childhood (mean age 9.9 years) and in adolescence (mean age 15.4 years): blood pressure, lipids, apolipoproteins (at 9.9 years only), glucose and insulin (at 15.4 years only), C reactive protein (CRP), and interleukin 6 (at 9.9 years only) were measured.

RESULTS: After adjustments for potential confounders (maternal age, education, body mass index (BMI), smoking, physical activity, parity, socioeconomic position, ethnicity, and offspring gestational age at 25(OH)D sampling; gender, age, and BMI at outcome assessment), maternal 25(OH)D was inversely associated with systolic blood pressure (-0.48 mm Hg difference per 50 nmol/L increase in 25(OH)D; 95% CI -0.95 to -0.01), Apo-B (-0.01 mg/dL difference; 95% CI -0.02 to -0.001), and CRP (-6.1% difference; 95% CI -11.5% to -0.3%) at age 9.9 years. These associations were not present for risk factors measured at 15.4 years, with the exception of a weak inverse association with CRP (-5.5% difference; 95% CI -11.4% to 0.8%). There was no strong evidence of associations with offspring triglycerides, glucose or insulin.

CONCLUSIONS: Our findings suggest that fetal exposure to 25(OH)D is unlikely to influence cardiovascular risk factors of individuals later in life.

Original language	English
Pages (from-to)	1849-1856
Number of pages	8
Journal	Heart
Volume	99
Issue number	24
DOIs	https://doi.org/10.1136/heartjnl-2013-303678
Publication status	Published - 15 Dec 2013

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adolescent
Adult
Cardiovascular Diseases
Child
Female
Follow-Up Studies
Great Britain
Humans
Incidence
Maternal Nutritional Physiological Phenomena
Pregnancy
Pregnancy Complications
Prospective Studies
Risk Factors
Vitamin D
Vitamin D Deficiency
Young Adult

Access to Document

10.1136/heartjnl-2013-303678

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Persistent link

THE PUBLIC HEALTH IMPORTANCE OF VITAMIN D: DETERMINING CAUSAL EFFECTS OF INTRAUTERINE AND LIFETIME EXPOSURE TO VITAMIN D
Lawlor, D. A. (Principal Investigator)
1/10/08 → 1/12/13
Project: Research
MRC TRAINING FELLOWSHIP FOR A FRASER: OBSTETRIC, LIFESTYLE & GENETIC DETERMINANTS OF VASCULAR METABLIC TRAITS
Lawlor, D. A. (Principal Investigator)
1/09/08 → 1/09/14
Project: Research
CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)
Davey Smith, G. (Principal Investigator)
1/09/07 → 1/09/13
Project: Research

Cite this

Williams, D. M., Fraser, A., Fraser, W. D., Hyppoenen, E., Smith, G. D., Deanfield, J., Hingorani, A., Sattar, N., & Lawlor, D. A. (2013). Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children. Heart, 99(24), 1849-1856. https://doi.org/10.1136/heartjnl-2013-303678

@article{249c2858a62c43ff871fc59089fc3439,

title = "Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children",

abstract = "OBJECTIVE: Lower maternal vitamin D status in pregnancy may be associated with increased offspring cardiovascular risk in later life, but evidence for this is scant. We examined associations of maternal total 25-hydroxyvitamin D (25(OH)D) in pregnancy with offspring cardiovascular risk factors assessed in childhood and adolescence.DESIGN: A longitudinal, prospective study.SETTING: The study was based on data from mother-offspring pairs in the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK prospective population-based birth cohort (N=4109).OUTCOME MEASURES: Offspring cardiovascular risk factors were measured in childhood (mean age 9.9 years) and in adolescence (mean age 15.4 years): blood pressure, lipids, apolipoproteins (at 9.9 years only), glucose and insulin (at 15.4 years only), C reactive protein (CRP), and interleukin 6 (at 9.9 years only) were measured.RESULTS: After adjustments for potential confounders (maternal age, education, body mass index (BMI), smoking, physical activity, parity, socioeconomic position, ethnicity, and offspring gestational age at 25(OH)D sampling; gender, age, and BMI at outcome assessment), maternal 25(OH)D was inversely associated with systolic blood pressure (-0.48 mm Hg difference per 50 nmol/L increase in 25(OH)D; 95\% CI -0.95 to -0.01), Apo-B (-0.01 mg/dL difference; 95\% CI -0.02 to -0.001), and CRP (-6.1\% difference; 95\% CI -11.5\% to -0.3\%) at age 9.9 years. These associations were not present for risk factors measured at 15.4 years, with the exception of a weak inverse association with CRP (-5.5\% difference; 95\% CI -11.4\% to 0.8\%). There was no strong evidence of associations with offspring triglycerides, glucose or insulin.CONCLUSIONS: Our findings suggest that fetal exposure to 25(OH)D is unlikely to influence cardiovascular risk factors of individuals later in life.",

keywords = "Adolescent, Adult, Cardiovascular Diseases, Child, Female, Follow-Up Studies, Great Britain, Humans, Incidence, Maternal Nutritional Physiological Phenomena, Pregnancy, Pregnancy Complications, Prospective Studies, Risk Factors, Vitamin D, Vitamin D Deficiency, Young Adult",

author = "Williams, \{Dylan M.\} and Abigail Fraser and Fraser, \{William D.\} and Elina Hyppoenen and Smith, \{George Davey\} and John Deanfield and Aroon Hingorani and Naveed Sattar and Lawlor, \{Debbie A.\}",

year = "2013",

month = dec,

day = "15",

doi = "10.1136/heartjnl-2013-303678",

language = "English",

volume = "99",

pages = "1849--1856",

journal = "Heart",

issn = "1355-6037",

publisher = "BMJ Publishing Group",

number = "24",

}

Williams, DM, Fraser, A, Fraser, WD, Hyppoenen, E, Smith, GD, Deanfield, J, Hingorani, A, Sattar, N & Lawlor, DA 2013, 'Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children', Heart, vol. 99, no. 24, pp. 1849-1856. https://doi.org/10.1136/heartjnl-2013-303678

Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children. / Williams, Dylan M.; Fraser, Abigail; Fraser, William D. et al.
In: Heart, Vol. 99, No. 24, 15.12.2013, p. 1849-1856.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence

T2 - findings from the Avon Longitudinal Study of Parents and Children

AU - Williams, Dylan M.

AU - Fraser, Abigail

AU - Fraser, William D.

AU - Hyppoenen, Elina

AU - Smith, George Davey

AU - Deanfield, John

AU - Hingorani, Aroon

AU - Sattar, Naveed

AU - Lawlor, Debbie A.

PY - 2013/12/15

Y1 - 2013/12/15

N2 - OBJECTIVE: Lower maternal vitamin D status in pregnancy may be associated with increased offspring cardiovascular risk in later life, but evidence for this is scant. We examined associations of maternal total 25-hydroxyvitamin D (25(OH)D) in pregnancy with offspring cardiovascular risk factors assessed in childhood and adolescence.DESIGN: A longitudinal, prospective study.SETTING: The study was based on data from mother-offspring pairs in the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK prospective population-based birth cohort (N=4109).OUTCOME MEASURES: Offspring cardiovascular risk factors were measured in childhood (mean age 9.9 years) and in adolescence (mean age 15.4 years): blood pressure, lipids, apolipoproteins (at 9.9 years only), glucose and insulin (at 15.4 years only), C reactive protein (CRP), and interleukin 6 (at 9.9 years only) were measured.RESULTS: After adjustments for potential confounders (maternal age, education, body mass index (BMI), smoking, physical activity, parity, socioeconomic position, ethnicity, and offspring gestational age at 25(OH)D sampling; gender, age, and BMI at outcome assessment), maternal 25(OH)D was inversely associated with systolic blood pressure (-0.48 mm Hg difference per 50 nmol/L increase in 25(OH)D; 95% CI -0.95 to -0.01), Apo-B (-0.01 mg/dL difference; 95% CI -0.02 to -0.001), and CRP (-6.1% difference; 95% CI -11.5% to -0.3%) at age 9.9 years. These associations were not present for risk factors measured at 15.4 years, with the exception of a weak inverse association with CRP (-5.5% difference; 95% CI -11.4% to 0.8%). There was no strong evidence of associations with offspring triglycerides, glucose or insulin.CONCLUSIONS: Our findings suggest that fetal exposure to 25(OH)D is unlikely to influence cardiovascular risk factors of individuals later in life.

AB - OBJECTIVE: Lower maternal vitamin D status in pregnancy may be associated with increased offspring cardiovascular risk in later life, but evidence for this is scant. We examined associations of maternal total 25-hydroxyvitamin D (25(OH)D) in pregnancy with offspring cardiovascular risk factors assessed in childhood and adolescence.DESIGN: A longitudinal, prospective study.SETTING: The study was based on data from mother-offspring pairs in the Avon Longitudinal Study of Parents and Children (ALSPAC), a UK prospective population-based birth cohort (N=4109).OUTCOME MEASURES: Offspring cardiovascular risk factors were measured in childhood (mean age 9.9 years) and in adolescence (mean age 15.4 years): blood pressure, lipids, apolipoproteins (at 9.9 years only), glucose and insulin (at 15.4 years only), C reactive protein (CRP), and interleukin 6 (at 9.9 years only) were measured.RESULTS: After adjustments for potential confounders (maternal age, education, body mass index (BMI), smoking, physical activity, parity, socioeconomic position, ethnicity, and offspring gestational age at 25(OH)D sampling; gender, age, and BMI at outcome assessment), maternal 25(OH)D was inversely associated with systolic blood pressure (-0.48 mm Hg difference per 50 nmol/L increase in 25(OH)D; 95% CI -0.95 to -0.01), Apo-B (-0.01 mg/dL difference; 95% CI -0.02 to -0.001), and CRP (-6.1% difference; 95% CI -11.5% to -0.3%) at age 9.9 years. These associations were not present for risk factors measured at 15.4 years, with the exception of a weak inverse association with CRP (-5.5% difference; 95% CI -11.4% to 0.8%). There was no strong evidence of associations with offspring triglycerides, glucose or insulin.CONCLUSIONS: Our findings suggest that fetal exposure to 25(OH)D is unlikely to influence cardiovascular risk factors of individuals later in life.

KW - Adolescent

KW - Adult

KW - Cardiovascular Diseases

KW - Child

KW - Female

KW - Follow-Up Studies

KW - Great Britain

KW - Humans

KW - Incidence

KW - Maternal Nutritional Physiological Phenomena

KW - Pregnancy

KW - Pregnancy Complications

KW - Prospective Studies

KW - Risk Factors

KW - Vitamin D

KW - Vitamin D Deficiency

KW - Young Adult

U2 - 10.1136/heartjnl-2013-303678

DO - 10.1136/heartjnl-2013-303678

M3 - Article (Academic Journal)

C2 - 24125739

SN - 1355-6037

VL - 99

SP - 1849

EP - 1856

JO - Heart

JF - Heart

IS - 24

ER -

Associations of maternal 25-hydroxyvitamin D in pregnancy with offspring cardiovascular risk factors in childhood and adolescence: findings from the Avon Longitudinal Study of Parents and Children

Abstract

UN SDGs

Keywords

Access to Document

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Projects

THE PUBLIC HEALTH IMPORTANCE OF VITAMIN D: DETERMINING CAUSAL EFFECTS OF INTRAUTERINE AND LIFETIME EXPOSURE TO VITAMIN D

MRC TRAINING FELLOWSHIP FOR A FRASER: OBSTETRIC, LIFESTYLE & GENETIC DETERMINANTS OF VASCULAR METABLIC TRAITS

CENTRE FOR CASUAL ANALYSES IN TRANSLATIONAL EPIDEMIOLOGY (CAiTE)

Cite this