Abstract
Background: Neprilysin (NEP) cleaves amyloid-β 1-42 (Aβ42) in the brain. Hence, we aimed to elucidate the effect of NEP on Aβ42 in cerebrospinal fluid (CSF) and on in vivo brain amyloid load using amyloid positron emission tomography (PET) with [11C]PiB (Pittsburgh compound B). In addition, associations with the biomarkers for neuronal injury, CSF-tau and FDG-PET, were investigated. Methods: Associations were calculated using global and voxel-based (SPM8) linear regression analyses in the same cohort of 23 highly characterized Alzheimer's disease patients. Results: CSF-NEP was significantly inversely associated with CSF-Aβ42 and positively with the extent of neuronal injury as measured by CSF-tau and FDG-PET. Conclusions: Our results on CSF-NEP are compatible with the assumption that local degradation, amongst other mechanisms of amyloid clearance, plays a role in the development of Alzheimer's pathology. In addition, CSF-NEP is associated with the extent and the rate of neurodegeneration.
Original language | English |
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Pages (from-to) | 43-50 |
Number of pages | 8 |
Journal | Neurodegenerative Diseases |
Volume | 19 |
Issue number | 1 |
Early online date | 2 Jul 2019 |
DOIs | |
Publication status | Published - 1 Aug 2019 |
Bibliographical note
The acceptance date for this record is provisional and based upon the month of publication for the article.Keywords
- Alzheimer's disease
- Amyloid clearance
- Cerebrospinal fluid
- CSF-Aβ
- CSF-tau
- FDG-PET
- Neprilysin
- Neuronal injury
- Pittsburgh compound B
- Positron emission tomography