Associations of time of day with cardiovascular disease risk factors measured in older men: results from the British Regional Heart Study

Claudio Sartini, Peter Whincup, SG Wannamethee, Barbara J Jefferis, Lucy T Lennon, Gordon D. O. Lowe, Paul Welsh, Naveed Sattar, Richard Morris

Research output: Contribution to journalArticle (Academic Journal)peer-review

4 Citations (Scopus)
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Abstract

Objective We estimated associations of time of day with cardiovascular disease (CVD) risk factors measured in older men.

Methods CVD risk factors (markers of inflammation and haemostasis, and cardiac markers) were measured on one occasion between 08:00 and 19:00 hours in 4252 men aged 60–79 years from the British Regional Heart Study. Linear models were used to estimate associations between time of day and risk factors. When an association was found, we examined whether the relationship between risk factors and cardiovascular mortality was affected by the adjustment for time of day using survival analyses.

Results N-terminal pro-brain natriuretic peptide (NT-proBNP) levels increased by 3.3% per hour (95% CI 1.9% to 4.8%), interleukin-6 (IL-6) increased by 2.6% per hour (95% CI 1.8% to 3.4%), while tissue plasminogen activator (t-PA) decreased by 3.3% per hour (95% CI 3.7% to 2.9%); these associations were unaffected by adjustment for possible confounding factors. The percentages of variation in these risk factors attributable to time of day were less than 2%. In survival analyses, the association of IL-6, NT-proBNP and t-PA with cardiovascular mortality was not affected by the adjustment for time of day. C reactive protein, fibrinogen, D-dimer, von Willebrand factor and cardiac troponin T showed no associations with time of day.

Conclusions In older men, markers of inflammation (IL-6), haemostasis (t-PA) and a cardiac marker (NT-proBNP) varied by time of day. The contribution of time of day to variations in these markers was small and did not appear to be relevant for the CVD risk prediction.
Original languageEnglish
Article numbere018264
Number of pages8
JournalBMJ Open
Volume7
Issue number11
Early online date12 Nov 2017
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Biological markers
  • Older adults
  • Cardiovascular disease
  • Diurnal variations

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