Assoiciation of the NRGI gene and schizophrenia: a meta-analysis

MR Munafo, D Thiselton, TG Clark, J Flint

Research output: Contribution to journalArticle (Academic Journal)peer-review

187 Citations (Scopus)

Abstract

We investigated the association of the NRG1 gene and schizophrenia using meta-analytic techniques, combining all published data while restricting our analysis to studies investigating the most commonly reported single marker (SNP8NRG221533). We also investigated whether ancestry (European vs East Asian) and study design (family-based vs case–control) moderated any association. We found no evidence for an association of SNP8NRG221533 with schizophrenia, and significant between-study heterogeneity, which persisted when family-based studies were combined separately. However, when haplotype-based P-values were combined, there was evidence in support of an association of NRG1 with schizophrenia, and no evidence of between-study heterogeneity. Our meta-analysis provides support for the association of NRG1 with schizophrenia, but indicates that firmly establishing the role of NRG1 gene in schizophrenia by genetic association requires much larger sample sizes than have hitherto been reported. Association analyses and replications should take place at the level of the gene, rather than at the level of SNP, haplotype, or functional variant. Meta-analysis would then be carried out on the basis of the combination of P-values.
Translated title of the contributionAssoiciation of the NRGI gene and schizophrenia: a meta-analysis
Original languageEnglish
Pages (from-to)539 - 546
Number of pages8
JournalMolecular Psychiatry
Volume11
DOIs
Publication statusPublished - Jun 2006

Bibliographical note

Publisher: Nature Publishing Group

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