Abstract
δ-Hydroxy allylic phosphine-oxides 5 undergo asymmetric epoxidation to yield epoxy alcohols 6 with high enantio- and diastereoselectivity. Kinetic resolutions are also successful, even with a chiral centre remote from the allylic hydroxyl, if that chiral centre bears a diphenylphosphinoyl group. The diphenylphosphinoyl group then exerts a novel anti-directing effect on the epoxidation.
Original language | English |
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Pages (from-to) | 7043-7046 |
Number of pages | 4 |
Journal | Tetrahedron Letters |
Volume | 33 |
Issue number | 46 |
DOIs | |
Publication status | Published - 10 Nov 1992 |