Asymmetric sulfur ylide mediated aziridination: Application in the synthesis of the side chain of taxol

VK Aggarwal*, JL Vasse

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

102 Citations (Scopus)

Abstract

Sulfur ylide methodology has been used to construct the Taxol side chain with a high degree of enantioselectivity via a trans-aziridine followed by stereospecific rearrangement of the trans-benzoylaziridine into a trans-oxazoline.

Original languageEnglish
Pages (from-to)3987-3990
Number of pages4
JournalOrganic Letters
Volume5
Issue number21
DOIs
Publication statusPublished - 16 Oct 2003

Keywords

  • VIC-AMINO ALCOHOLS
  • IN-SITU GENERATION
  • ENANTIOSELECTIVE SYNTHESIS
  • CHIRAL AZIRIDINES
  • IMINES
  • EPOXIDATION
  • ROUTE
  • CYCLOPROPANATION
  • REGIODIVERGENT
  • REARRANGEMENT

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