Asymmetric synthesis of indole homo-Michael adducts via dynamic kinetic Friedel-Crafts alkylation with cyclopropanes

Steven M. Wales, Morgan M. Walker, Jeffrey S. Johnson*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

113 Citations (Scopus)

Abstract

An enantioconvergent Friedel-Crafts alkylation of indoles with donor-acceptor cyclopropanes is described. The reaction is catalyzed by pybox•MgI2 and proceeds via a type I dynamic kinetic asymmetric transformation (DyKAT).

Original languageEnglish
Pages (from-to)2558-2561
Number of pages4
JournalOrganic Letters
Volume15
Issue number10
DOIs
Publication statusPublished - 17 May 2013

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