Projects per year
Abstract
Nonstabilized α-O-substituted tertiary organolithium species are difficult to generate, and the α-S-substituted analogues are configurationally unstable. We now report that they can both be generated easily and trapped with a range of electrophiles with high enantioselectivity, providing ready access to a range of enantioenriched tertiary alcohols and thiols. The configurational stability of the α-S-organolithium species was enhanced by using a less coordinating solvent and short reaction times.
| Original language | English |
|---|---|
| Pages (from-to) | 10835-10839 |
| Number of pages | 5 |
| Journal | Angewandte Chemie - International Edition |
| Volume | 56 |
| Issue number | 36 |
| Early online date | 7 Aug 2017 |
| DOIs | |
| Publication status | Published - 28 Aug 2017 |
Research Groups and Themes
- BCS and TECS CDTs
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Dive into the research topics of 'Asymmetric Synthesis of Tertiary Alcohols and Thiols via Nonstabilized Tertiary a-Oxy- and a-Thio-Substituted Organolithium Species'. Together they form a unique fingerprint.Projects
- 3 Finished
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A 13C NMR Coldprobe to Underpin Chemistry Research.
Butts, C. P. (Principal Investigator)
28/02/14 → 29/11/17
Project: Research
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
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Changing the Synthesis Landscape with Boron at the Helm: from Chiral Organometallics to Assembly Line Synthesis
Aggarwal, V. K. (Principal Investigator)
14/05/12 → 13/01/18
Project: Research
Student theses
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Lithiation and Borylation of Secondary O- and S- Substituted Hindered Benzoates
Songara, P. (Author), Russell, C. (Supervisor) & Aggarwal, V. (Supervisor), 11 May 2021Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)
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