Asymmetric synthesis of tertiary thiols and thioethers

Jonathan Clayden*, Paul MacLellan

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

138 Citations (Scopus)

Abstract

Enantiomerically pure tertiary thiols provide a major synthetic challenge, and despite the importance of chiral sulfur-containing compounds in biological and medicinal chemistry, surprisingly few effective methods are suitable for the asymmetric synthesis of tertiary thiols. This review details the most practical of the methods available.

Original languageEnglish
Article numberA68
Pages (from-to)582-595
Number of pages14
JournalBeilstein Journal of Organic Chemistry
Volume7
DOIs
Publication statusPublished - 10 May 2011

Keywords

  • Asymmetric synthesis
  • Organolithium
  • Substitution
  • Sulfur
  • Thiol

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