Asymmetric synthesis of tertiary thiols and thioethers

Jonathan Clayden; Paul MacLellan

doi:10.3762/bjoc.7.68

Asymmetric synthesis of tertiary thiols and thioethers

Jonathan Clayden^*, Paul MacLellan

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

138 Citations (Scopus)

Abstract

Enantiomerically pure tertiary thiols provide a major synthetic challenge, and despite the importance of chiral sulfur-containing compounds in biological and medicinal chemistry, surprisingly few effective methods are suitable for the asymmetric synthesis of tertiary thiols. This review details the most practical of the methods available.

Original language	English
Article number	A68
Pages (from-to)	582-595
Number of pages	14
Journal	Beilstein Journal of Organic Chemistry
Volume	7
DOIs	https://doi.org/10.3762/bjoc.7.68
Publication status	Published - 10 May 2011

Keywords

Asymmetric synthesis
Organolithium
Substitution
Sulfur
Thiol

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10.3762/bjoc.7.68

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