At the crossroads of skeletal responses to estrogen and exercise

Research output: Contribution to journalArticle (Academic Journal)peer-review

17 Citations (Scopus)


The recent observation that mice deficient in estrogen receptor alpha (ERalpha) have an impaired response to mechanical strain suggests that ERalpha plays an important role in mediating the response of the skeleton to mechanical loading as well as to estrogen. In view of previous findings that estrogen deficiency leads to a fall in ERalpha numbers, postmenopausal bone loss might result from the impaired response of bone to mechanical strain caused by deficient ERalpha signalling.
Original languageEnglish
Pages (from-to)441-3
Number of pages3
JournalTrends in Endocrinology and Metabolism
Issue number10
Publication statusPublished - 2003


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