Autophagy, lipophagy and lysosomal lipid storage disorders

Carl Ward, Nuria Martinez-Lopez, Elsje G. Otten, Bernadette Carroll, Dorothea Maetzel, Rajat Singh*, Sovan Sarkar, Viktor I. Korolchuk

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

143 Citations (Scopus)
280 Downloads (Pure)


Autophagy is a catabolic process with an essential function in the maintenance of cellular and tissue homeostasis. It is primarily recognised for its role in the degradation of dysfunctional proteins and unwanted organelles, however in recent years the range of autophagy substrates has also been extended to lipids. Degradation of lipids via autophagy is termed lipophagy. The ability of autophagy to contribute to the maintenance of lipo-homeostasis becomes particularly relevant in the context of genetic lysosomal storage disorders where perturbations of autophagic flux have been suggested to contribute to the disease aetiology. Here we review recent discoveries of the molecular mechanisms mediating lipid turnover by the autophagy pathways. We further focus on the relevance of autophagy, and specifically lipophagy, to the disease mechanisms. Moreover, autophagy is also discussed as a potential therapeutic target in several key lysosomal storage disorders.

Original languageEnglish
Pages (from-to)269-284
Number of pages16
JournalBiochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
Issue number4
Early online date14 Jan 2016
Publication statusPublished - 1 Apr 2016


  • Autophagy
  • Lipid metabolism
  • Lipid storage disorders


Dive into the research topics of 'Autophagy, lipophagy and lysosomal lipid storage disorders'. Together they form a unique fingerprint.

Cite this