Autoregulatory and paracrine control of synaptic and behavioral plasticity by octopaminergic signaling

Alex C Koon, James Ashley, Romina Barria, Shamik DasGupta, Ruth Brain, Scott Waddell, Mark J Alkema, Vivian Budnik

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Adrenergic signaling has important roles in synaptic plasticity and metaplasticity. However, the underlying mechanisms of these functions remain poorly understood. We investigated the role of octopamine, the invertebrate counterpart of adrenaline and noradrenaline, in synaptic and behavioral plasticity in Drosophila. We found that an increase in locomotor speed induced by food deprivation was accompanied by an activity- and octopamine-dependent extension of octopaminergic arbors and that the formation and maintenance of these arbors required electrical activity. Growth of octopaminergic arbors was controlled by a cAMP- and CREB-dependent positive-feedback mechanism that required Octβ2R octopamine autoreceptors. Notably, this autoregulation was necessary for the locomotor response. In addition, octopamine neurons regulated the expansion of excitatory glutamatergic neuromuscular arbors through Octβ2Rs on glutamatergic motor neurons. Our results provide a mechanism for global regulation of excitatory synapses, presumably to maintain synaptic and behavioral plasticity in a dynamic range.

Original languageEnglish
Pages (from-to)190-9
Number of pages10
JournalNature Neuroscience
Volume14
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Animals
  • Animals, Genetically Modified
  • Cyclic AMP/metabolism
  • Cyclic AMP Response Element-Binding Protein/metabolism
  • Drosophila
  • Homeostasis
  • Hunger/physiology
  • Motor Activity/physiology
  • Motor Neurons/metabolism
  • Neuronal Plasticity/physiology
  • Octopamine/metabolism
  • Receptors, Biogenic Amine/metabolism
  • Synapses/physiology
  • Synaptic Transmission/physiology

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