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Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.
|Translated title of the contribution||Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy|
|Pages (from-to)||541 - 547|
|Number of pages||7|
|Publication status||Published - Jan 2011|