Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

X Hong; E.M.P.H van Dijk; S.R Hall; J.B Götte; N.F van Hulst; H Gersen

doi:10.1021/nl1034489

Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

X Hong, E.M.P.H van Dijk, S.R Hall, J.B Götte, N.F van Hulst, H Gersen

Research output: Contribution to journal › Article (Academic Journal) › peer-review

39 Citations (Scopus)

Abstract

Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.

Translated title of the contribution	Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy
Original language	English
Pages (from-to)	541 - 547
Number of pages	7
Journal	Nano Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1021/nl1034489
Publication status	Published - Jan 2011

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Publisher: American Chemical Society

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10.1021/nl1034489

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ULTRASENSITIVE DETECTION OF NANOMETER SIZED METAL PARTICLES IN LIVING CELLS
Gersen, H.
1/05/08 → 1/05/11
Project: Research

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AU - van Dijk, E.M.P.H

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AU - van Hulst, N.F

AU - Gersen, H

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AB - Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.

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Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

Abstract

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ULTRASENSITIVE DETECTION OF NANOMETER SIZED METAL PARTICLES IN LIVING CELLS

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