Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

X Hong; E.M.P.H van Dijk; S.R Hall; J.B Götte; N.F van Hulst; H Gersen

doi:10.1021/nl1034489

Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

X Hong, E.M.P.H van Dijk, S.R Hall, J.B Götte, N.F van Hulst, H Gersen

Research output: Contribution to journal › Article (Academic Journal)

39 Citations (Scopus)

Abstract

Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.

Original language	English
Pages (from-to)	541 - 547
Number of pages	7
Journal	Nano Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1021/nl1034489
Publication status	Published - Jan 2011

Bibliographical note

Publisher: American Chemical Society

Access to Document

10.1021/nl1034489

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Projects

1 Finished

ULTRASENSITIVE DETECTION OF NANOMETER SIZED METAL PARTICLES IN LIVING CELLS

Gersen, H.

1/05/08 → 1/05/11

Project: Research

Cite this

Hong, X., van Dijk, E. M. P. H., Hall, S. R., Götte, J. B., van Hulst, N. F., & Gersen, H. (2011). Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy. Nano Letters, 11(2), 541 - 547. https://doi.org/10.1021/nl1034489

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