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Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.
Bibliographical notePublisher: American Chemical Society
Hong, X., van Dijk, E. M. P. H., Hall, S. R., Götte, J. B., van Hulst, N. F., & Gersen, H. (2011). Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy. Nano Letters, 11(2), 541 - 547. https://doi.org/10.1021/nl1034489