Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

X Hong; E.M.P.H van Dijk; S.R Hall; J.B Götte; N.F van Hulst; H Gersen

doi:10.1021/nl1034489

Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

X Hong, E.M.P.H van Dijk, S.R Hall, J.B Götte, N.F van Hulst, H Gersen

Research output: Contribution to journal › Article (Academic Journal) › peer-review

42 Citations (Scopus)

Abstract

Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.

Translated title of the contribution	Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy
Original language	English
Pages (from-to)	541 - 547
Number of pages	7
Journal	Nano Letters
Volume	11
Issue number	2
DOIs	https://doi.org/10.1021/nl1034489
Publication status	Published - Jan 2011

Bibliographical note

Publisher: American Chemical Society

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10.1021/nl1034489

http://pubs.acs.org/doi/abs/10.1021/nl1034489

Cite this

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title = "Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy",

abstract = "Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.",

author = "X Hong and {van Dijk}, E.M.P.H and S.R Hall and J.B G{\"o}tte and {van Hulst}, N.F and H Gersen",

note = "Publisher: American Chemical Society",

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T1 - Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

AU - Hong, X

AU - van Dijk, E.M.P.H

AU - Hall, S.R

AU - Götte, J.B

AU - van Hulst, N.F

AU - Gersen, H

N1 - Publisher: American Chemical Society

PY - 2011/1

Y1 - 2011/1

N2 - Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.

AB - Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.

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DO - 10.1021/nl1034489

M3 - Article (Academic Journal)

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JF - Nano Letters

SN - 1530-6984

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ER -

Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

Abstract

Bibliographical note

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Fingerprint

Direct evidence of lack of colocalisation of fluorescently labelled gold labels used in correlative light electron microscopy

An All-Optical Method For Characterising Individual Fluorescent Nanodiamonds

On the sensitivity of Interferometric Cross-Polarisation Microscopy for nanoparticle detection in the near-infrared.

ULTRASENSITIVE DETECTION OF NANOMETER SIZED METAL PARTICLES IN LIVING CELLS

Cite this

Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

Abstract

Bibliographical note

Access to Document

Other files and links

Fingerprint

Research output

Direct evidence of lack of colocalisation of fluorescently labelled gold labels used in correlative light electron microscopy

An All-Optical Method For Characterising Individual Fluorescent Nanodiamonds

On the sensitivity of Interferometric Cross-Polarisation Microscopy for nanoparticle detection in the near-infrared.

Projects

ULTRASENSITIVE DETECTION OF NANOMETER SIZED METAL PARTICLES IN LIVING CELLS

Cite this