Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

X Hong, E.M.P.H van Dijk, S.R Hall, J.B Götte, N.F van Hulst, H Gersen

Research output: Contribution to journalArticle (Academic Journal)

39 Citations (Scopus)

Abstract

Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.
Original languageEnglish
Pages (from-to)541 - 547
Number of pages7
JournalNano Letters
Volume11
Issue number2
DOIs
Publication statusPublished - Jan 2011

Bibliographical note

Publisher: American Chemical Society

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