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Background-Free Detection of Single 5 nm Nanoparticles through Interferometric Cross-Polarization Microscopy

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)541 - 547
Number of pages7
JournalNano Letters
Issue number2
DatePublished - Jan 2011


Metal nanoparticles play a key role in sensing and imaging. Here we demonstrate the detection of metal particles down to 5 nm in size with a signal-to-noise ratio of 7 using interferometric cross-polarization microscopy at ultralow excitation powers (1 μW) compatible with single molecule detection. The method is background-free and induces no heating as it operates far from plasmonic resonance. The combination of unlimited observation time and protein-sized metal nanoparticles has great potential for biophysical applications.

Additional information

Publisher: American Chemical Society

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