Abstract
Biological cell function crucially relies on the accuracy of RNA sequences, transcribed from the DNA genetic code. To ensure sufficiently high fidelity in the face of high spontaneous error rates during transcription, error correction mechanisms must play an important role. A particular mechanism of transcriptional error correction involves backtracking of the RNA polymerase and RNA cleavage. Motivated by recent single molecule experiments characterizing the dynamics of backtracking, we present a microscopic model of this editing process. We show that such a mechanism can yield error frequencies that are in agreement with in vivo observations.
Translated title of the contribution | Bactracking and proofreading in DNA transcription |
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Original language | English |
Article number | 258101 |
Number of pages | 4 |
Journal | Physical Review Letters |
Volume | 102 |
Issue number | 25 |
DOIs | |
Publication status | Published - Jun 2009 |
Bibliographical note
Publisher: APSResearch Groups and Themes
- Engineering Mathematics Research Group