Abstract
The interaction between colistin and tigecycline against eight well-characterized NDM-1-producing Enterobacteriaceae strains
was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free
drug peak, trough, and average 24-h serum concentrations. Colistin sulfate and methanesulfonate alone showed good early bactericidal
activity, often with subsequent regrowth. Tigecycline alone had poor activity. Addition of tigecycline to colistin does
not produce increased bacterial killing; instead, it may cause antagonism at lower concentrations.
was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free
drug peak, trough, and average 24-h serum concentrations. Colistin sulfate and methanesulfonate alone showed good early bactericidal
activity, often with subsequent regrowth. Tigecycline alone had poor activity. Addition of tigecycline to colistin does
not produce increased bacterial killing; instead, it may cause antagonism at lower concentrations.
| Original language | English |
|---|---|
| Article number | 6 |
| Pages (from-to) | 3441-3443 |
| Number of pages | 3 |
| Journal | Antimicrobial Agents and Chemotherapy |
| Volume | 56 |
| Issue number | 6 |
| Early online date | 5 Mar 2012 |
| DOIs | |
| Publication status | Published - 12 Jun 2012 |
Keywords
- NDN-1, Colistin, Tigecycline, Bactericidality