Bactericidal activity of multiple combinations of Colistin and Tigecycline against NDM-1 producing Enterobacteriaceae.

Mahableshwar S Albur, Alan Noel, Karen Bowker, Alasdair P MacGowan

Research output: Contribution to journalArticle (Academic Journal)

34 Citations (Scopus)

Abstract

The interaction between colistin and tigecycline against eight well-characterized NDM-1-producing Enterobacteriaceae strains
was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free
drug peak, trough, and average 24-h serum concentrations. Colistin sulfate and methanesulfonate alone showed good early bactericidal
activity, often with subsequent regrowth. Tigecycline alone had poor activity. Addition of tigecycline to colistin does
not produce increased bacterial killing; instead, it may cause antagonism at lower concentrations.
Original languageEnglish
Article number6
Pages (from-to)3441-3443
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume56
Issue number6
Early online date5 Mar 2012
DOIs
Publication statusPublished - 12 Jun 2012

Keywords

  • NDN-1, Colistin, Tigecycline, Bactericidality

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