Abstract
Bag-1 is an anti-apoptotic protein that exhibits altered expression in many malignancies,
including oral squamous cell carcinoma. The bag-1 gene gives rise to different protein
products with different subcellular localisations through alternative translational initiation
sites. In oral squamous cell carcinoma, cytoplasmic expression has been associated with metastasis
to regional lymph nodes and poor prognosis. In contrast, the longest Bag-1 isoform is
nuclear and may regulate differentiation in oral epithelium. In this review, the functions of
the three isoforms of Bag-1 expressed in oral epithelial cells are discussed in relation to their
contribution to oral carcinogenesis.
| Translated title of the contribution | Bag-1 proteins in oral squamous cell carcinoma |
|---|---|
| Original language | English |
| Pages (from-to) | 94 - 102 |
| Number of pages | 9 |
| Journal | Oral Oncology |
| Volume | 45 |
| DOIs | |
| Publication status | Published - Feb 2009 |