BAlaS: fast, interactive and accessible computational alanine-scanning using BudeAlaScan

Christopher W Wood*, Amaurys Avila Ibarra, Gail J Bartlett, Dek N Woolfson, Richard B Sessions*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Motivation
In experimental protein engineering, alanine-scanning mutagenesis involves the replacement of selected residues with alanine to determine the energetic contribution of each side chain to forming an interaction. For example, it is often used to study protein-protein interactions. However, such experiments can be time-consuming and costly, which has led to the development of programs for performing computational alanine-scanning mutagenesis (CASM) to guide experiments. While programs are available for this, there is a need for a real-time web application that is accessible to non-expert users.
Original languageEnglish
Article numberbtaa026
Number of pages3
JournalBioinformatics
Early online date13 Jan 2020
DOIs
Publication statusE-pub ahead of print - 13 Jan 2020

Structured keywords

  • Bristol BioDesign Institute

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