Basal ganglia volume and shape in anorexia nervosa

Jenni Leppanen, Valentina Cardi, Felicity Sedgewick, Janet Treasure, Kate Tchanturia

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Abstract

Background
Reward-centred models have proposed that anomalies in the basal ganglia circuitry that underlies reward learning and habit formation perpetuate anorexia nervosa (AN). The present study aimed to investigate the volume and shape of key basal ganglia regions, including the bilateral caudate, putamen, nucleus accumbens (NAcc), and globus pallidus in AN.

Methods
The present study combined data from two existing studies resulting in a sample size of 46 women with AN and 56 age-matched healthy comparison (HC) women. Group differences in volume and shape of the regions of interest were examined. Within the AN group, the impact of eating disorder characteristics on volume and shape of the basal ganglia regions were also explored.

Results
The shape analyses revealed inward deformations in the left caudate, right NAcc, and bilateral ventral and internus globus pallidus, and outward deformations in the right middle and posterior globus pallidus in the AN group.

Conclusions
The present findings appear to fit with the theoretical models suggesting that there are alterations in the basal ganglia regions associated with habit formation and reward processing in AN. Further investigation of structural and functional connectivity of these regions in AN as well as their role in recovery would be of interest.
Original languageEnglish
Article number104480
Number of pages8
JournalAppetite
Volume144
DOIs
Publication statusPublished - 2 Oct 2019

Structured keywords

  • SoE Centre for Psychological Approaches for Studying Education

Keywords

  • basal ganglia
  • pallidum
  • caudate
  • nucleus accumbens
  • reward

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  • Cite this

    Leppanen, J., Cardi, V., Sedgewick, F., Treasure, J., & Tchanturia, K. (2019). Basal ganglia volume and shape in anorexia nervosa. Appetite, 144, [104480]. https://doi.org/10.1016/j.appet.2019.104480