Skip to content

Basal ganglia volume and shape in anorexia nervosa

Research output: Contribution to journalArticle

Original languageEnglish
Article number104480
Number of pages8
JournalAppetite
Volume144
DOIs
DateAccepted/In press - 1 Oct 2019
DatePublished (current) - 2 Oct 2019

Abstract

Background
Reward-centred models have proposed that anomalies in the basal ganglia circuitry that underlies reward learning and habit formation perpetuate anorexia nervosa (AN). The present study aimed to investigate the volume and shape of key basal ganglia regions, including the bilateral caudate, putamen, nucleus accumbens (NAcc), and globus pallidus in AN.

Methods
The present study combined data from two existing studies resulting in a sample size of 46 women with AN and 56 age-matched healthy comparison (HC) women. Group differences in volume and shape of the regions of interest were examined. Within the AN group, the impact of eating disorder characteristics on volume and shape of the basal ganglia regions were also explored.

Results
The shape analyses revealed inward deformations in the left caudate, right NAcc, and bilateral ventral and internus globus pallidus, and outward deformations in the right middle and posterior globus pallidus in the AN group.

Conclusions
The present findings appear to fit with the theoretical models suggesting that there are alterations in the basal ganglia regions associated with habit formation and reward processing in AN. Further investigation of structural and functional connectivity of these regions in AN as well as their role in recovery would be of interest.

    Research areas

  • basal ganglia, pallidum, caudate, nucleus accumbens, reward

Download statistics

No data available

Documents

Documents

  • Full-text PDF (final published version)

    Rights statement: This is the final published version of the article (version of record). It first appeared online via Elsevier at https://www.sciencedirect.com/science/article/pii/S0195666319300558 . Please refer to any applicable terms of use of the publisher.

    Final published version, 443 KB, PDF document

    Licence: CC BY

DOI

View research connections

Related faculties, schools or groups