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BASP1 interacts with estrogen receptor α and modifies the tamoxifen response

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BASP1 interacts with estrogen receptor α and modifies the tamoxifen response. / Marsh, Lindsey; Carrera, Samantha; Shandilya, Jayasha; Heesom, Kate; Davidson, Andrew; Medler, K F; Roberts, Stefan.

In: Cell Death and Disease, Vol. 8, No. 5, e2771, 11.05.2017.

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Marsh, L, Carrera, S, Shandilya, J, Heesom, K, Davidson, A, Medler, KF & Roberts, S 2017, 'BASP1 interacts with estrogen receptor α and modifies the tamoxifen response', Cell Death and Disease, vol. 8, no. 5, e2771. https://doi.org/10.1038/cddis.2017.179

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Marsh L, Carrera S, Shandilya J, Heesom K, Davidson A, Medler KF et al. BASP1 interacts with estrogen receptor α and modifies the tamoxifen response. Cell Death and Disease. 2017 May 11;8(5). e2771. https://doi.org/10.1038/cddis.2017.179

Author

Marsh, Lindsey ; Carrera, Samantha ; Shandilya, Jayasha ; Heesom, Kate ; Davidson, Andrew ; Medler, K F ; Roberts, Stefan. / BASP1 interacts with estrogen receptor α and modifies the tamoxifen response. In: Cell Death and Disease. 2017 ; Vol. 8, No. 5.

Bibtex

@article{d295248d1802418bb330a73cd0fbe7ca,
title = "BASP1 interacts with estrogen receptor α and modifies the tamoxifen response",
abstract = "Tamoxifen binds to estrogen receptor α (ERα) to elicit distinct responses that vary by cell/tissue type and status, but the factors that determine these differential effects are unknown. Here we report that the transcriptional corepressor BASP1 interacts with ERα and in breast cancer cells, this interaction is enhanced by tamoxifen. We find that BASP1 acts as a major selectivity factor in the transcriptional response of breast cancer cells to tamoxifen. 40{\%} of the genes that are regulated by tamoxifen in breast cancer cells are BASP1-dependent, including several genes that are associated with tamoxifen resistance. BASP1 elicits tumour-suppressor activity in breast cancer cells and enhances the anti-tumourigenic effects of tamoxifen treatment. Moreover, BASP1 is expressed in breast cancer tissue and is associated with increased patient survival. Our data has identified BASP1 as an ERα cofactor that plays a central role in the transcriptional and anti-tumourigenic effects of tamoxifen.",
keywords = "BASP1, Estrogen receptor, ERα, Tamoxifen, Breast cancer, Transcription",
author = "Lindsey Marsh and Samantha Carrera and Jayasha Shandilya and Kate Heesom and Andrew Davidson and Medler, {K F} and Stefan Roberts",
year = "2017",
month = "5",
day = "11",
doi = "10.1038/cddis.2017.179",
language = "English",
volume = "8",
journal = "Cell Death and Disease",
issn = "2041-4889",
publisher = "Springer Nature",
number = "5",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - BASP1 interacts with estrogen receptor α and modifies the tamoxifen response

AU - Marsh, Lindsey

AU - Carrera, Samantha

AU - Shandilya, Jayasha

AU - Heesom, Kate

AU - Davidson, Andrew

AU - Medler, K F

AU - Roberts, Stefan

PY - 2017/5/11

Y1 - 2017/5/11

N2 - Tamoxifen binds to estrogen receptor α (ERα) to elicit distinct responses that vary by cell/tissue type and status, but the factors that determine these differential effects are unknown. Here we report that the transcriptional corepressor BASP1 interacts with ERα and in breast cancer cells, this interaction is enhanced by tamoxifen. We find that BASP1 acts as a major selectivity factor in the transcriptional response of breast cancer cells to tamoxifen. 40% of the genes that are regulated by tamoxifen in breast cancer cells are BASP1-dependent, including several genes that are associated with tamoxifen resistance. BASP1 elicits tumour-suppressor activity in breast cancer cells and enhances the anti-tumourigenic effects of tamoxifen treatment. Moreover, BASP1 is expressed in breast cancer tissue and is associated with increased patient survival. Our data has identified BASP1 as an ERα cofactor that plays a central role in the transcriptional and anti-tumourigenic effects of tamoxifen.

AB - Tamoxifen binds to estrogen receptor α (ERα) to elicit distinct responses that vary by cell/tissue type and status, but the factors that determine these differential effects are unknown. Here we report that the transcriptional corepressor BASP1 interacts with ERα and in breast cancer cells, this interaction is enhanced by tamoxifen. We find that BASP1 acts as a major selectivity factor in the transcriptional response of breast cancer cells to tamoxifen. 40% of the genes that are regulated by tamoxifen in breast cancer cells are BASP1-dependent, including several genes that are associated with tamoxifen resistance. BASP1 elicits tumour-suppressor activity in breast cancer cells and enhances the anti-tumourigenic effects of tamoxifen treatment. Moreover, BASP1 is expressed in breast cancer tissue and is associated with increased patient survival. Our data has identified BASP1 as an ERα cofactor that plays a central role in the transcriptional and anti-tumourigenic effects of tamoxifen.

KW - BASP1

KW - Estrogen receptor

KW - ERα

KW - Tamoxifen

KW - Breast cancer

KW - Transcription

U2 - 10.1038/cddis.2017.179

DO - 10.1038/cddis.2017.179

M3 - Article

C2 - 28492543

AN - SCOPUS:85019245605

VL - 8

JO - Cell Death and Disease

JF - Cell Death and Disease

SN - 2041-4889

IS - 5

M1 - e2771

ER -