Bayesian alignment using hierarchical models, with applications in protein bioinformatics

PJ Green, K Mardia

Research output: Contribution to journalArticle (Academic Journal)

65 Citations (Scopus)

Abstract

An important problem in shape analysis is to match configurations of points in space after filtering out some geometrical transformation. In this paper we introduce hierarchical models for such tasks, in which the points in the configurations are either unlabelled or have at most a partial labelling constraining the matching, and in which some points may only appear in one of the configurations. We derive procedures for simultaneous inference about the matching and the transformation, using a Bayesian approach. Our hierarchical model is based on a Poisson process for hidden true point locations; this leads to considerable mathematical simplification and efficiency of implementation of EM and Markov chain Monte Carlo algorithms. We find a novel use for classical distributions from directional statistics in a conditionally conjugate specification for the case where the geometrical transformation includes an unknown rotation. Throughout, we focus on the case of affine or rigid motion transformations. Under a broad parametric family of loss functions, an optimal Bayesian point estimate of the matching matrix can be constructed that depends only on a single parameter of the family. Our methods are illustrated by two applications from bioinformatics. The first problem is of matching protein gels in two dimensions, and the second consists of aligning active sites of proteins in three dimensions. In the latter case, we also use information related to the grouping of the amino acids, as an example of a more general capability of our methodology to include partial labelling information. We discuss some open problems and suggest directions for future work.
Translated title of the contributionBayesian alignment using hierarchical models, with applications in protein bioinformatics
Original languageEnglish
Pages (from-to)235 - 254
Number of pages20
JournalBiometrika
Volume93 (2)
DOIs
Publication statusPublished - Jun 2006

Bibliographical note

Publisher: Oxford University Press

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