Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats

Claire A. Hales, Conor J. Houghton, Emma S.J. Robinson*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

12 Citations (Scopus)
318 Downloads (Pure)

Abstract

Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders. Until the recent discovery of the rapid onset antidepressant action of ketamine, pharmacological treatments for MDD were limited to conventional antidepressant drugs with delayed clinical efficacy. Using a judgement bias task, this study has investigated whether the temporal differences observed in patients would be reflected in affective biases and decision making behaviour in rodents. The diffusion model was also used to investigate the underlying decision making processes. Positive biases were induced in this task over timeframes that mirror the rapid versus delayed antidepressant efficacy of the drugs in clinical populations. Diffusion modelling revealed that the antidepressants tested also have different effects on decision making processes, suggesting they may act through different neurobiological substrates. This combination of behaviour and computational modelling may provide a useful approach to further investigate the mechanisms underlying rapid antidepressant effect and assess potential new treatments.

Original languageEnglish
Pages (from-to)1268-1280
Number of pages13
JournalEuropean Neuropsychopharmacology
Volume27
Issue number12
Early online date31 Oct 2017
DOIs
Publication statusPublished - Dec 2017

Keywords

  • Antidepressants
  • Behaviour
  • Diffusion model
  • Judgement bias
  • Ketamine
  • Rodent

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