Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study

Ian P Hall; John D Blakey; Khalid A Al Balushi; Amanda Wheatley; Ian Sayers; Marcus E Pembrey; Susan M Ring; Wendy L McArdle; David P Strachan

doi:10.1016/S0140-6736(06)69287-8

Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study

Ian P Hall, John D Blakey, Khalid A Al Balushi, Amanda Wheatley, Ian Sayers, Marcus E Pembrey, Susan M Ring, Wendy L McArdle, David P Strachan

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

92 Citations (Scopus)

Abstract

Functionally relevant polymorphisms of the beta2-adrenoceptor gene (ADRB2) are common in white populations, but their contribution to the burden of airways disease in the population is uncertain. We aimed to relate the long-term prevalence of asthma or wheeze to functional coding region polymorphisms in the ADRB2 gene.

Original language	English
Pages (from-to)	771-9
Number of pages	9
Journal	Lancet
Volume	368
Issue number	9537
DOIs	https://doi.org/10.1016/S0140-6736(06)69287-8
Publication status	Published - 2006

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@article{7bcc8ce884504176806899c8d19b16ee,

title = "Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study",

abstract = "Functionally relevant polymorphisms of the beta2-adrenoceptor gene (ADRB2) are common in white populations, but their contribution to the burden of airways disease in the population is uncertain. We aimed to relate the long-term prevalence of asthma or wheeze to functional coding region polymorphisms in the ADRB2 gene.",

author = "Hall, \{Ian P\} and Blakey, \{John D\} and \{Al Balushi\}, \{Khalid A\} and Amanda Wheatley and Ian Sayers and Pembrey, \{Marcus E\} and Ring, \{Susan M\} and McArdle, \{Wendy L\} and Strachan, \{David P\}",

year = "2006",

doi = "10.1016/S0140-6736(06)69287-8",

language = "English",

volume = "368",

pages = "771--9",

journal = "Lancet",

issn = "1474-547X",

publisher = "Elsevier B.V.",

number = "9537",

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TY - JOUR

T1 - Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort

T2 - a genetic association study

AU - Hall, Ian P

AU - Blakey, John D

AU - Al Balushi, Khalid A

AU - Wheatley, Amanda

AU - Sayers, Ian

AU - Pembrey, Marcus E

AU - Ring, Susan M

AU - McArdle, Wendy L

AU - Strachan, David P

PY - 2006

Y1 - 2006

N2 - Functionally relevant polymorphisms of the beta2-adrenoceptor gene (ADRB2) are common in white populations, but their contribution to the burden of airways disease in the population is uncertain. We aimed to relate the long-term prevalence of asthma or wheeze to functional coding region polymorphisms in the ADRB2 gene.

AB - Functionally relevant polymorphisms of the beta2-adrenoceptor gene (ADRB2) are common in white populations, but their contribution to the burden of airways disease in the population is uncertain. We aimed to relate the long-term prevalence of asthma or wheeze to functional coding region polymorphisms in the ADRB2 gene.

U2 - 10.1016/S0140-6736(06)69287-8

DO - 10.1016/S0140-6736(06)69287-8

M3 - Article (Academic Journal)

C2 - 16935688

SN - 1474-547X

VL - 368

SP - 771

EP - 779

JO - Lancet

JF - Lancet

IS - 9537

ER -

Beta2-adrenoceptor polymorphisms and asthma from childhood to middle age in the British 1958 birth cohort: a genetic association study

Abstract

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