Beyond apical ballooning: computational modelling reveals morphological features of Takotsubo cardiomyopathy

Giulia Pontecorboli, Giovanni Biglino, Elena Giulia Milano, Froso Sophocleous, Benedetta Biffi, Amardeep Ghosh Dastidar, Silvia Schievano, Carlo Di Mario, Chiara Bucciarelli-Ducci

Research output: Contribution to journalArticle (Academic Journal)

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Abstract

Takotsubo cardiomyopathy (TCM) is characterized by transient myocardial dysfunction, typically at the left ventricular (LV) apex. Its pathophysiology and recovery mechanisms remain unknown. We investigated LV morphology and deformation in n = 28 TCM patients. Patients with MRI within 5 days from admission (“early TCM”) showed reduced LVEF and higher ventricular volumes, but no differences in ECG, global strains or myocardial oedema. Statistical shape modelling described LV size (Mode 1), apical sphericity (Mode 2) and height (Mode 3). Significant differences in Mode 1 suggest that “early TCM” LV remodeling is mainly influenced by a change in ventricular size rather than apical sphericity.

Original languageEnglish
Pages (from-to)1103-1106
Number of pages4
JournalComputer Methods in Biomechanics and Biomedical Engineering
Volume22
Issue number14
Early online date3 Jul 2019
DOIs
Publication statusPublished - 26 Oct 2019

Keywords

  • Takotsubo cardiomyopathy
  • cardiac magnetic resonance
  • statistical shape modelling
  • computational modelling
  • myocardial deformation

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