Biased Estimates in Mendelian Randomization Studies Conducted in Unrepresentative Samples

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Abstract

To the Editor: Large cohort studies have transformed our ability to evaluate complex exposure-outcome relationships. However, these studies are typically not representative of the source population from which they are sampled because of selection at recruitment, attrition over time (in prospective studies), or both. For example, in UK Biobank, the response rate was approximately 5%, and the resulting sample was healthier and more highly educated than the general population of the United Kingdom...
Original languageEnglish
Pages (from-to)181
Number of pages1
JournalJAMA Cardiology
Volume3
Issue number2
Early online date13 Dec 2017
DOIs
Publication statusE-pub ahead of print - 13 Dec 2017

Structured keywords

  • Brain and Behaviour
  • Tobacco and Alcohol

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