Abstract
The glycolytic nature of malignant tumors contributes to high levels of extracellular acidity in the tumor microenvironment. Tumor acidity is a driving force in invasion and metastases. Recently, it has been shown that buffering of extracellular acidity through systemic administration of oral bicarbonate can inhibit the spread of metastases in a mouse model for metastatic breast cancer. While these findings are compelling, recent assessments into the use of oral bicarbonate as a cancer intervention reveal limitations.
| Original language | English |
|---|---|
| Pages (from-to) | 235 |
| Journal | BMC Cancer |
| Volume | 11 |
| DOIs | |
| Publication status | Published - 2011 |
Keywords
- Administration, Oral
- Animals
- Sodium Bicarbonate
- Bicarbonates
- Antineoplastic Agents
- Humans
- Hydrogen-Ion Concentration
- Tumor Microenvironment
- Tumor Burden
- Breast Neoplasms
- Disease Models, Animal
- Mice
- Cell Line, Tumor
- Dichloroacetic Acid
- Cell Hypoxia
- Lactates
- Lung Neoplasms
- Mice, SCID
- Female
- Survival Analysis
