Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures

Khrongkhwan Akkarachaneeyakorn; Mei Li; Joe Harris; Sean A. Davis; Stephen Mann

doi:10.1021/cm5027305

Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures

Khrongkhwan Akkarachaneeyakorn, Mei Li, Joe Harris, Sean A. Davis, Stephen Mann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal)

11 Citations (Scopus)

Abstract

Morphologically complex amorphous calcium phosphate nanostructures are synthesized within supersaturated water-in-oil miniemulsions stabilized by a mixture of a calcium bis(2-ethylhexyl)phosphate (Ca(DEHP)₂) surfactant and poly(ethylene oxide)₁₉-poly(propylene oxide)₆₉-poly(ethylene oxide)₁₉ (P123) triblock copolymer. Solvent evaporation at room temperature results in self-supporting viscous organogels comprising an interconnected network of calcium phosphate nanofilaments embedded within a continuous polymer/surfactant matrix. The P123/DEHP/calcium phosphate organogels are employed as a bioactive filler for the occlusion of exposed dentine tubules using a standard bovine tooth model.

Original language	English
Pages (from-to)	5965-5972
Number of pages	8
Journal	Chemistry of Materials
Volume	26
Issue number	20
DOIs	https://doi.org/10.1021/cm5027305
Publication status	Published - 28 Oct 2014

Keywords

HYDROPHILIC BLOCK-COPOLYMERS
AMORPHOUS CALCIUM-PHOSPHATE
NANOPARTICLES
CRYSTALLIZATION
MINERALIZATION
MICROEMULSIONS

Access to Document

10.1021/cm5027305

Link to publication in Scopus

Cite this

Akkarachaneeyakorn, K., Li, M., Harris, J., Davis, S. A., & Mann, S. (2014). Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures. Chemistry of Materials, 26(20), 5965-5972. https://doi.org/10.1021/cm5027305

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abstract = "Morphologically complex amorphous calcium phosphate nanostructures are synthesized within supersaturated water-in-oil miniemulsions stabilized by a mixture of a calcium bis(2-ethylhexyl)phosphate (Ca(DEHP)2) surfactant and poly(ethylene oxide)19-poly(propylene oxide)69-poly(ethylene oxide)19 (P123) triblock copolymer. Solvent evaporation at room temperature results in self-supporting viscous organogels comprising an interconnected network of calcium phosphate nanofilaments embedded within a continuous polymer/surfactant matrix. The P123/DEHP/calcium phosphate organogels are employed as a bioactive filler for the occlusion of exposed dentine tubules using a standard bovine tooth model.",

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AU - Akkarachaneeyakorn, Khrongkhwan

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AU - Harris, Joe

AU - Davis, Sean A.

AU - Mann, Stephen

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KW - HYDROPHILIC BLOCK-COPOLYMERS

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