Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures

Khrongkhwan Akkarachaneeyakorn; Mei Li; Joe Harris; Sean A. Davis; Stephen Mann

doi:10.1021/cm5027305

Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures

Khrongkhwan Akkarachaneeyakorn, Mei Li, Joe Harris, Sean A. Davis, Stephen Mann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

12 Citations (Scopus)

Abstract

Morphologically complex amorphous calcium phosphate nanostructures are synthesized within supersaturated water-in-oil miniemulsions stabilized by a mixture of a calcium bis(2-ethylhexyl)phosphate (Ca(DEHP)₂) surfactant and poly(ethylene oxide)₁₉-poly(propylene oxide)₆₉-poly(ethylene oxide)₁₉ (P123) triblock copolymer. Solvent evaporation at room temperature results in self-supporting viscous organogels comprising an interconnected network of calcium phosphate nanofilaments embedded within a continuous polymer/surfactant matrix. The P123/DEHP/calcium phosphate organogels are employed as a bioactive filler for the occlusion of exposed dentine tubules using a standard bovine tooth model.

Original language	English
Pages (from-to)	5965-5972
Number of pages	8
Journal	Chemistry of Materials
Volume	26
Issue number	20
DOIs	https://doi.org/10.1021/cm5027305
Publication status	Published - 28 Oct 2014

Keywords

HYDROPHILIC BLOCK-COPOLYMERS
AMORPHOUS CALCIUM-PHOSPHATE
NANOPARTICLES
CRYSTALLIZATION
MINERALIZATION
MICROEMULSIONS

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10.1021/cm5027305

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@article{efc031d6a52f4d52874dbd0ceebd15a4,

title = "Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures",

abstract = "Morphologically complex amorphous calcium phosphate nanostructures are synthesized within supersaturated water-in-oil miniemulsions stabilized by a mixture of a calcium bis(2-ethylhexyl)phosphate (Ca(DEHP)2) surfactant and poly(ethylene oxide)19-poly(propylene oxide)69-poly(ethylene oxide)19 (P123) triblock copolymer. Solvent evaporation at room temperature results in self-supporting viscous organogels comprising an interconnected network of calcium phosphate nanofilaments embedded within a continuous polymer/surfactant matrix. The P123/DEHP/calcium phosphate organogels are employed as a bioactive filler for the occlusion of exposed dentine tubules using a standard bovine tooth model.",

keywords = "HYDROPHILIC BLOCK-COPOLYMERS, AMORPHOUS CALCIUM-PHOSPHATE, NANOPARTICLES, CRYSTALLIZATION, MINERALIZATION, MICROEMULSIONS",

author = "Khrongkhwan Akkarachaneeyakorn and Mei Li and Joe Harris and Davis, {Sean A.} and Stephen Mann",

year = "2014",

month = oct,

day = "28",

doi = "10.1021/cm5027305",

language = "English",

volume = "26",

pages = "5965--5972",

journal = "Chemistry of Materials",

issn = "0897-4756",

publisher = "American Chemical Society",

number = "20",

}

Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures. / Akkarachaneeyakorn, Khrongkhwan; Li, Mei; Harris, Joe; Davis, Sean A.; Mann, Stephen.

In: Chemistry of Materials, Vol. 26, No. 20, 28.10.2014, p. 5965-5972.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures

AU - Akkarachaneeyakorn, Khrongkhwan

AU - Li, Mei

AU - Harris, Joe

AU - Davis, Sean A.

AU - Mann, Stephen

PY - 2014/10/28

Y1 - 2014/10/28

N2 - Morphologically complex amorphous calcium phosphate nanostructures are synthesized within supersaturated water-in-oil miniemulsions stabilized by a mixture of a calcium bis(2-ethylhexyl)phosphate (Ca(DEHP)2) surfactant and poly(ethylene oxide)19-poly(propylene oxide)69-poly(ethylene oxide)19 (P123) triblock copolymer. Solvent evaporation at room temperature results in self-supporting viscous organogels comprising an interconnected network of calcium phosphate nanofilaments embedded within a continuous polymer/surfactant matrix. The P123/DEHP/calcium phosphate organogels are employed as a bioactive filler for the occlusion of exposed dentine tubules using a standard bovine tooth model.

AB - Morphologically complex amorphous calcium phosphate nanostructures are synthesized within supersaturated water-in-oil miniemulsions stabilized by a mixture of a calcium bis(2-ethylhexyl)phosphate (Ca(DEHP)2) surfactant and poly(ethylene oxide)19-poly(propylene oxide)69-poly(ethylene oxide)19 (P123) triblock copolymer. Solvent evaporation at room temperature results in self-supporting viscous organogels comprising an interconnected network of calcium phosphate nanofilaments embedded within a continuous polymer/surfactant matrix. The P123/DEHP/calcium phosphate organogels are employed as a bioactive filler for the occlusion of exposed dentine tubules using a standard bovine tooth model.

KW - HYDROPHILIC BLOCK-COPOLYMERS

KW - AMORPHOUS CALCIUM-PHOSPHATE

KW - NANOPARTICLES

KW - CRYSTALLIZATION

KW - MINERALIZATION

KW - MICROEMULSIONS

UR - http://www.scopus.com/inward/record.url?scp=84908302796&partnerID=8YFLogxK

U2 - 10.1021/cm5027305

DO - 10.1021/cm5027305

M3 - Article (Academic Journal)

VL - 26

SP - 5965

EP - 5972

JO - Chemistry of Materials

JF - Chemistry of Materials

SN - 0897-4756

IS - 20

ER -

Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures

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Dr Sean A Davis

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Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures

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Dr Sean A Davis

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