Bioactive hybrid organogels based on miniemulsion synthesis of morphologically complex polymer/surfactant/calcium phosphate nanostructures

Khrongkhwan Akkarachaneeyakorn, Mei Li, Joe Harris, Sean A. Davis, Stephen Mann*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)

11 Citations (Scopus)

Abstract

Morphologically complex amorphous calcium phosphate nanostructures are synthesized within supersaturated water-in-oil miniemulsions stabilized by a mixture of a calcium bis(2-ethylhexyl)phosphate (Ca(DEHP)2) surfactant and poly(ethylene oxide)19-poly(propylene oxide)69-poly(ethylene oxide)19 (P123) triblock copolymer. Solvent evaporation at room temperature results in self-supporting viscous organogels comprising an interconnected network of calcium phosphate nanofilaments embedded within a continuous polymer/surfactant matrix. The P123/DEHP/calcium phosphate organogels are employed as a bioactive filler for the occlusion of exposed dentine tubules using a standard bovine tooth model.

Original languageEnglish
Pages (from-to)5965-5972
Number of pages8
JournalChemistry of Materials
Volume26
Issue number20
DOIs
Publication statusPublished - 28 Oct 2014

Keywords

  • HYDROPHILIC BLOCK-COPOLYMERS
  • AMORPHOUS CALCIUM-PHOSPHATE
  • NANOPARTICLES
  • CRYSTALLIZATION
  • MINERALIZATION
  • MICROEMULSIONS

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