Abstract
Objectives
To compare the effect of bioavailable gluconate-chelated stannous fluoride (SnF2) toothpaste with control toothpastes for treatment of dentine hypersensitivity (DH) and enamel erosion.
Data and sources
A Procter & Gamble Oral Care archive of clinical studies was reviewed from 2000 to 2020. Eligible studies were Randomised Controlled Trials (RCTs) investigating bioavailable gluconate-chelated SnF2 toothpaste efficacy compared to controls in adult participants measured following tactile (Yeaple force) and/or evaporative stimuli (Schiff score) in-vivo, duration <2 months (DH); or by erosive toothwear (profilometry) from in-situ samples, duration 10-15 days. Two authors independently assessed eligibility and resolved disagreements by discussion. A meta-analysis was undertaken and Risk of Bias (RoB) assessed using the Cochrane collaboration RoB tool for randomized parallel-group and cross-over trials.
Results
Fourteen RCTs (1287 participants) assessed DH relief and Six RCTs (184 participants) enamel erosion protection. For DH SnF2 toothpastes provided a 57% (evaporative air) and 142% (tactile) benefit versus negative controls (sodium fluoride/monofluorophosphate, 8 studies; p<0.001). Compared to positive controls (potassium nitrate or arginine, 6 studies), a 22% advantage (p=0.036) was seen for evaporative air. In erosion studies, SnF2 toothpastes provided an 83% benefit versus control toothpastes (arginine or sodium fluoride; p<0.001) with a change (95%CI) in average surface profilometry level (µm) of -2.02(-2.85, -1.20).
Conclusions
The use of these bioavailable SnF2 toothpastes, as part of a daily oral hygiene regimen, will provide patients with enamel erosion protection, combined with alleviation of DH pain when present, improving quality of life.
Original language | English |
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Article number | 103566 |
Number of pages | 10 |
Journal | Journal of Dentistry |
Volume | 105 (2021) |
Early online date | 28 Dec 2020 |
DOIs | |
Publication status | E-pub ahead of print - 28 Dec 2020 |
Keywords
- Dentine hypersensitivity
- tooth erosion
- Stannous fluoride
- meta-analysis
- pain
- dentifrices