TY - JOUR
T1 - Bioavailable Gluconate Chelated Stannous Fluoride Dentifrice Meta-Analyses
T2 - Effects on Dentine Hypersensitivity and Enamel Erosion
AU - West, Nicola X
AU - He, Tao
AU - Zou, Yuanshu
AU - DiGennaro, Joe
AU - Biesbrock, Aaron
AU - Davies, Maria
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Objectives
To compare the effect of bioavailable gluconate-chelated stannous fluoride (SnF2) toothpaste with control toothpastes for treatment of dentine hypersensitivity (DH) and enamel erosion.
Data and sources
A Procter & Gamble Oral Care archive of clinical studies was reviewed from 2000 to 2020. Eligible studies were Randomised Controlled Trials (RCTs) investigating bioavailable gluconate-chelated SnF2 toothpaste efficacy compared to controls in adult participants measured following tactile (Yeaple force) and/or evaporative stimuli (Schiff score) in-vivo, duration <2 months (DH); or by erosive toothwear (profilometry) from in-situ samples, duration 10-15 days. Two authors independently assessed eligibility and resolved disagreements by discussion. A meta-analysis was undertaken and Risk of Bias (RoB) assessed using the Cochrane collaboration RoB tool for randomized parallel-group and cross-over trials.
Results
Fourteen RCTs (1287 participants) assessed DH relief and Six RCTs (184 participants) enamel erosion protection. For DH SnF2 toothpastes provided a 57% (evaporative air) and 142% (tactile) benefit versus negative controls (sodium fluoride/monofluorophosphate, 8 studies; p<0.001). Compared to positive controls (potassium nitrate or arginine, 6 studies), a 22% advantage (p=0.036) was seen for evaporative air. In erosion studies, SnF2 toothpastes provided an 83% benefit versus control toothpastes (arginine or sodium fluoride; p<0.001) with a change (95%CI) in average surface profilometry level (µm) of -2.02(-2.85, -1.20).
Conclusions
The use of these bioavailable SnF2 toothpastes, as part of a daily oral hygiene regimen, will provide patients with enamel erosion protection, combined with alleviation of DH pain when present, improving quality of life.
AB - Objectives
To compare the effect of bioavailable gluconate-chelated stannous fluoride (SnF2) toothpaste with control toothpastes for treatment of dentine hypersensitivity (DH) and enamel erosion.
Data and sources
A Procter & Gamble Oral Care archive of clinical studies was reviewed from 2000 to 2020. Eligible studies were Randomised Controlled Trials (RCTs) investigating bioavailable gluconate-chelated SnF2 toothpaste efficacy compared to controls in adult participants measured following tactile (Yeaple force) and/or evaporative stimuli (Schiff score) in-vivo, duration <2 months (DH); or by erosive toothwear (profilometry) from in-situ samples, duration 10-15 days. Two authors independently assessed eligibility and resolved disagreements by discussion. A meta-analysis was undertaken and Risk of Bias (RoB) assessed using the Cochrane collaboration RoB tool for randomized parallel-group and cross-over trials.
Results
Fourteen RCTs (1287 participants) assessed DH relief and Six RCTs (184 participants) enamel erosion protection. For DH SnF2 toothpastes provided a 57% (evaporative air) and 142% (tactile) benefit versus negative controls (sodium fluoride/monofluorophosphate, 8 studies; p<0.001). Compared to positive controls (potassium nitrate or arginine, 6 studies), a 22% advantage (p=0.036) was seen for evaporative air. In erosion studies, SnF2 toothpastes provided an 83% benefit versus control toothpastes (arginine or sodium fluoride; p<0.001) with a change (95%CI) in average surface profilometry level (µm) of -2.02(-2.85, -1.20).
Conclusions
The use of these bioavailable SnF2 toothpastes, as part of a daily oral hygiene regimen, will provide patients with enamel erosion protection, combined with alleviation of DH pain when present, improving quality of life.
KW - Dentine hypersensitivity
KW - tooth erosion
KW - Stannous fluoride
KW - meta-analysis
KW - pain
KW - dentifrices
U2 - 10.1016/j.jdent.2020.103566
DO - 10.1016/j.jdent.2020.103566
M3 - Article (Academic Journal)
C2 - 33383100
SN - 0300-5712
VL - 105 (2021)
JO - Journal of Dentistry
JF - Journal of Dentistry
M1 - 103566
ER -