Bioavailable Gluconate Chelated Stannous Fluoride Dentifrice Meta-Analyses: Effects on Dentine Hypersensitivity and Enamel Erosion

Nicola X West*, Tao He*, Yuanshu Zou*, Joe DiGennaro*, Aaron Biesbrock*, Maria Davies*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)
133 Downloads (Pure)


Objectives To compare the effect of bioavailable gluconate-chelated stannous fluoride (SnF2) toothpaste with control toothpastes for treatment of dentine hypersensitivity (DH) and enamel erosion. Data and sources A Procter & Gamble Oral Care archive of clinical studies was reviewed from 2000 to 2020. Eligible studies were Randomised Controlled Trials (RCTs) investigating bioavailable gluconate-chelated SnF2 toothpaste efficacy compared to controls in adult participants measured following tactile (Yeaple force) and/or evaporative stimuli (Schiff score) in-vivo, duration <2 months (DH); or by erosive toothwear (profilometry) from in-situ samples, duration 10-15 days. Two authors independently assessed eligibility and resolved disagreements by discussion. A meta-analysis was undertaken and Risk of Bias (RoB) assessed using the Cochrane collaboration RoB tool for randomized parallel-group and cross-over trials. Results Fourteen RCTs (1287 participants) assessed DH relief and Six RCTs (184 participants) enamel erosion protection. For DH SnF2 toothpastes provided a 57% (evaporative air) and 142% (tactile) benefit versus negative controls (sodium fluoride/monofluorophosphate, 8 studies; p<0.001). Compared to positive controls (potassium nitrate or arginine, 6 studies), a 22% advantage (p=0.036) was seen for evaporative air. In erosion studies, SnF2 toothpastes provided an 83% benefit versus control toothpastes (arginine or sodium fluoride; p<0.001) with a change (95%CI) in average surface profilometry level (µm) of -2.02(-2.85, -1.20). Conclusions The use of these bioavailable SnF2 toothpastes, as part of a daily oral hygiene regimen, will provide patients with enamel erosion protection, combined with alleviation of DH pain when present, improving quality of life.
Original languageEnglish
Article number103566
Number of pages10
JournalJournal of Dentistry
Volume105 (2021)
Early online date28 Dec 2020
Publication statusE-pub ahead of print - 28 Dec 2020


  • Dentine hypersensitivity
  • tooth erosion
  • Stannous fluoride
  • meta-analysis
  • pain
  • dentifrices


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