Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases

Bo Yuan, Abigail Page, Christopher P. Worrall, Franck Escalettes, Simon C. Willies, Joseph J W McDouall, Nicholas J. Turner, Jonathan Clayden

Research output: Contribution to journalArticle (Academic Journal)

35 Citations (Scopus)

Abstract

All roads lead to ⋯ atropisomeric diaryl ethers containing a benzylic hydroxy group and an aldehyde unit. The isomers were synthesized in enantiomerically enriched form by desymmetrizing atroposelective enzymatic oxidation (with a galactose oxidase (GOase) variant) or reduction (with a ketoreductase (KRED); see scheme).

Original languageEnglish
Pages (from-to)7010-7013
Number of pages4
JournalAngewandte Chemie - International Edition
Volume49
Issue number39
Early online date16 Aug 2010
DOIs
Publication statusPublished - 17 Sep 2010

Keywords

  • Asymmetric synthesis atropisomerism biocatalysis diaryl ethers enzymes

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