TY - JOUR
T1 - Biocatalytic desymmetrization of an atropisomer with both an enantioselective oxidase and ketoreductases
AU - Yuan, Bo
AU - Page, Abigail
AU - Worrall, Christopher P.
AU - Escalettes, Franck
AU - Willies, Simon C.
AU - McDouall, Joseph J W
AU - Turner, Nicholas J.
AU - Clayden, Jonathan
PY - 2010/9/17
Y1 - 2010/9/17
N2 - All roads lead to ⋯ atropisomeric diaryl ethers containing a benzylic hydroxy group and an aldehyde unit. The isomers were synthesized in enantiomerically enriched form by desymmetrizing atroposelective enzymatic oxidation (with a galactose oxidase (GOase) variant) or reduction (with a ketoreductase (KRED); see scheme).
AB - All roads lead to ⋯ atropisomeric diaryl ethers containing a benzylic hydroxy group and an aldehyde unit. The isomers were synthesized in enantiomerically enriched form by desymmetrizing atroposelective enzymatic oxidation (with a galactose oxidase (GOase) variant) or reduction (with a ketoreductase (KRED); see scheme).
KW - Asymmetric synthesis atropisomerism biocatalysis diaryl ethers enzymes
UR - http://www.scopus.com/inward/record.url?scp=77956914045&partnerID=8YFLogxK
U2 - 10.1002/anie.201002580
DO - 10.1002/anie.201002580
M3 - Article (Academic Journal)
C2 - 20715245
AN - SCOPUS:77956914045
SN - 1433-7851
VL - 49
SP - 7010
EP - 7013
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
IS - 39
ER -