Biochemical, Clinical, Demographic and Imaging biomarkers for disease progression in knee osteoarthritis

Yulia Liem; Andrew Judge; Yunfei Li; Mohammed Sharif

doi:10.2217/bmm-2021-0579

Biochemical, Clinical, Demographic and Imaging biomarkers for disease progression in knee osteoarthritis

Yulia Liem, Andrew Judge, Yunfei Li, Mohammed Sharif^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

5 Citations (Scopus)

94 Downloads (Pure)

Abstract

Aim: To identify prognostic biomarker(s) for knee osteoarthritis (OA) in the Osteoarthritis Initiative (OAI) cohort. Methods: Multilevel regression was used to determine the association between baseline biomarkers and change in biomarkers from baseline to 24 months with clinical and radiographic OA progression over 48 months of follow-up. Results: Higher values of baseline urinary CTXII were consistently associated with an increased risk of OA disease progression outcomes: Kellgren & Lawrence grade (odds ratio [OR]: 1.15, 95% CI: 1.03–1.28); medial joint space narrowing (OR: 1.06, 95% CI: 1.02–1.10); lateral osteophytes (OR: 1.05, 95% CI: 1.01–1.10); joint space width (regression coefficient: -0.005, 95% CI: -0.008–0.001); and Western Ontario and McMaster Universities Arthritis Index pain scores (OR: 1.02, 95% CI: 1.01–1.04). Changes in serum PIIANP and serum COMP over 24 months were associated with clinical disease progression. Conclusion: Urinary CTXII showed stronger associations with radiographic OA and appears to be a reliable prognostic marker, while changes in other biomarkers were found in early symptomatic OA, supporting the phasic nature of OA.

Original language	English
Pages (from-to)	633–645
Number of pages	13
Journal	Biomarkers in Medicine
Volume	16
Issue number	8
Early online date	25 Apr 2022
DOIs	https://doi.org/10.2217/bmm-2021-0579
Publication status	E-pub ahead of print - 25 Apr 2022

Bibliographical note

Funding Information:
This study was supported by funding from a self-funded overseas PhD student (Y Li), Higher Education Funding Council for England, Versus Arthritis, and Joint China Scholarship Council-University of Bristol Scholarship Scheme. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

Publisher Copyright:
© 2022 The Authors.

Access to Document

10.2217/bmm-2021-0579

Full-text PDF (final published version)
This is the final published version of the article (version of record). It first appeared online via Future Science Group at https://doi.org/10.2217/bmm-2021-0579. Please refer to any applicable terms of use of the publisher.
Final published version, 1.37 MBLicence: CC BY

Handle.net

Persistent link

Embargoed Document

Full-text PDF (accepted author manuscript)
Accepted author manuscript, 399 KB
Request copy

Cite this

@article{9e4811968dfd4f468781cda837eaacd0,

title = "Biochemical, Clinical, Demographic and Imaging biomarkers for disease progression in knee osteoarthritis",

abstract = "Aim: To identify prognostic biomarker(s) for knee osteoarthritis (OA) in the Osteoarthritis Initiative (OAI) cohort. Methods: Multilevel regression was used to determine the association between baseline biomarkers and change in biomarkers from baseline to 24 months with clinical and radiographic OA progression over 48 months of follow-up. Results: Higher values of baseline urinary CTXII were consistently associated with an increased risk of OA disease progression outcomes: Kellgren & Lawrence grade (odds ratio [OR]: 1.15, 95% CI: 1.03–1.28); medial joint space narrowing (OR: 1.06, 95% CI: 1.02–1.10); lateral osteophytes (OR: 1.05, 95% CI: 1.01–1.10); joint space width (regression coefficient: -0.005, 95% CI: -0.008–0.001); and Western Ontario and McMaster Universities Arthritis Index pain scores (OR: 1.02, 95% CI: 1.01–1.04). Changes in serum PIIANP and serum COMP over 24 months were associated with clinical disease progression. Conclusion: Urinary CTXII showed stronger associations with radiographic OA and appears to be a reliable prognostic marker, while changes in other biomarkers were found in early symptomatic OA, supporting the phasic nature of OA.",

author = "Yulia Liem and Andrew Judge and Yunfei Li and Mohammed Sharif",

note = "Funding Information: This study was supported by funding from a self-funded overseas PhD student (Y Li), Higher Education Funding Council for England, Versus Arthritis, and Joint China Scholarship Council-University of Bristol Scholarship Scheme. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: {\textcopyright} 2022 The Authors.",

year = "2022",

month = apr,

day = "25",

doi = "10.2217/bmm-2021-0579",

language = "English",

volume = "16",

pages = "633–645",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Future Medicine Ltd.",

number = "8",

}

TY - JOUR

T1 - Biochemical, Clinical, Demographic and Imaging biomarkers for disease progression in knee osteoarthritis

AU - Liem, Yulia

AU - Judge, Andrew

AU - Li, Yunfei

AU - Sharif, Mohammed

N1 - Funding Information: This study was supported by funding from a self-funded overseas PhD student (Y Li), Higher Education Funding Council for England, Versus Arthritis, and Joint China Scholarship Council-University of Bristol Scholarship Scheme. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. Publisher Copyright: © 2022 The Authors.

PY - 2022/4/25

Y1 - 2022/4/25

N2 - Aim: To identify prognostic biomarker(s) for knee osteoarthritis (OA) in the Osteoarthritis Initiative (OAI) cohort. Methods: Multilevel regression was used to determine the association between baseline biomarkers and change in biomarkers from baseline to 24 months with clinical and radiographic OA progression over 48 months of follow-up. Results: Higher values of baseline urinary CTXII were consistently associated with an increased risk of OA disease progression outcomes: Kellgren & Lawrence grade (odds ratio [OR]: 1.15, 95% CI: 1.03–1.28); medial joint space narrowing (OR: 1.06, 95% CI: 1.02–1.10); lateral osteophytes (OR: 1.05, 95% CI: 1.01–1.10); joint space width (regression coefficient: -0.005, 95% CI: -0.008–0.001); and Western Ontario and McMaster Universities Arthritis Index pain scores (OR: 1.02, 95% CI: 1.01–1.04). Changes in serum PIIANP and serum COMP over 24 months were associated with clinical disease progression. Conclusion: Urinary CTXII showed stronger associations with radiographic OA and appears to be a reliable prognostic marker, while changes in other biomarkers were found in early symptomatic OA, supporting the phasic nature of OA.

AB - Aim: To identify prognostic biomarker(s) for knee osteoarthritis (OA) in the Osteoarthritis Initiative (OAI) cohort. Methods: Multilevel regression was used to determine the association between baseline biomarkers and change in biomarkers from baseline to 24 months with clinical and radiographic OA progression over 48 months of follow-up. Results: Higher values of baseline urinary CTXII were consistently associated with an increased risk of OA disease progression outcomes: Kellgren & Lawrence grade (odds ratio [OR]: 1.15, 95% CI: 1.03–1.28); medial joint space narrowing (OR: 1.06, 95% CI: 1.02–1.10); lateral osteophytes (OR: 1.05, 95% CI: 1.01–1.10); joint space width (regression coefficient: -0.005, 95% CI: -0.008–0.001); and Western Ontario and McMaster Universities Arthritis Index pain scores (OR: 1.02, 95% CI: 1.01–1.04). Changes in serum PIIANP and serum COMP over 24 months were associated with clinical disease progression. Conclusion: Urinary CTXII showed stronger associations with radiographic OA and appears to be a reliable prognostic marker, while changes in other biomarkers were found in early symptomatic OA, supporting the phasic nature of OA.

U2 - 10.2217/bmm-2021-0579

DO - 10.2217/bmm-2021-0579

M3 - Article (Academic Journal)

C2 - 35465685

SN - 1752-0363

VL - 16

SP - 633

EP - 645

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 8

ER -

Biochemical, Clinical, Demographic and Imaging biomarkers for disease progression in knee osteoarthritis

Abstract

Bibliographical note

Access to Document

Handle.net

Embargoed Document

Fingerprint

Cite this