Biocompatibility of platinum-metallized silicone rubber: in vivo and in vitro evaluation

V Vince, M.A. Thil, C. Veraart, I.M. Colin, J. Delbeke

Research output: Contribution to journalArticle (Academic Journal)peer-review

18 Citations (Scopus)

Abstract

Silicone rubber is commonly used for biomedical applications, including implanted cuff electrodes for both recording and stimulation of peripheral nerves. This study was undertaken to evaluate the consequences of a new platinum metallization method on the biocompatibility of silicone rubber cuff electrodes. This method was introduced in order to allow the manufacture of spiral nerve cuff electrodes with a large number of contacts. The metallization process, implying silicone coating with poly(methyl methacrylate) (PMMA), its activation by an excimer laser and subsequent electroless metal deposition, led to a new surface microtexture. The neutral red cytotoxicity assay procedure was first applied in vitro on BALB/c 3T3 fibroblasts in order to analyze the cellular response elicited by the studied material. An in vivo assay was then performed to investigate the tissue reaction after chronic subcutaneous implantation of the metallized material. Results demonstrate that silicone rubber biocompatibility is not altered by the new platinum metallization method.
Translated title of the contributionBiocompatibility of platinum-metallized silicone rubber: in vivo and in vitro evaluation
Original languageEnglish
Pages (from-to)173 - 188
JournalJournal of biomaterials science. Polymer edition
Volume15 (2)
Publication statusPublished - 2004

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