TY - JOUR
T1 - Biodiversity of the human oral mycobiome in health and disease
AU - Bandara, Herath Mudiyansalage Herath Nihal
AU - Panduwawala, Chamila P.
AU - Samaranayake, Lakshman Perera
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The organisms that colonize the human body over a lifetime are diverse, extensive and gargantuan. A fair proportion of the microbiota that constitutes this human microbiome live within our oral cavities mostly as harmonious associates causing only sporadic disease. An important core constituent of the microbiome is the mycobiome, representing various fungal genera. Up until recently, only a few species of fungi, mainly Candida species, were thought to constitute the human oral mycobiome. The reasons for this are manifold, although the uncultivable nature of many fungi in conventional laboratory media, and their complex genetic composition seem to be the major factors which eluded their detection over the years. Nevertheless, recent advances in computing and high throughput sequencing such as next generation sequencing (NGS) platforms have provided us a panoramic view of a totally new world of fungi that are human oral co-habitués. Their diversity is perplexing, and functionality yet to be deciphered. Here we provide a glimpse of what is currently known of the oral mycobiome, in health and disease, with some future perspectives.
AB - The organisms that colonize the human body over a lifetime are diverse, extensive and gargantuan. A fair proportion of the microbiota that constitutes this human microbiome live within our oral cavities mostly as harmonious associates causing only sporadic disease. An important core constituent of the microbiome is the mycobiome, representing various fungal genera. Up until recently, only a few species of fungi, mainly Candida species, were thought to constitute the human oral mycobiome. The reasons for this are manifold, although the uncultivable nature of many fungi in conventional laboratory media, and their complex genetic composition seem to be the major factors which eluded their detection over the years. Nevertheless, recent advances in computing and high throughput sequencing such as next generation sequencing (NGS) platforms have provided us a panoramic view of a totally new world of fungi that are human oral co-habitués. Their diversity is perplexing, and functionality yet to be deciphered. Here we provide a glimpse of what is currently known of the oral mycobiome, in health and disease, with some future perspectives.
KW - biodiversity
KW - fungi
KW - high‐throughput sequencing
KW - human microbiome
KW - oral mycobiome
UR - http://www.scopus.com/inward/record.url?scp=85061565382&partnerID=8YFLogxK
U2 - 10.1111/odi.12899
DO - 10.1111/odi.12899
M3 - Article (Academic Journal)
C2 - 29786923
AN - SCOPUS:85061565382
SN - 1354-523X
VL - 25
SP - 363
EP - 371
JO - Oral Diseases
JF - Oral Diseases
IS - 2
ER -