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Biodiversity of the human oral mycobiome in health and disease

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)363-371
Number of pages9
JournalOral Diseases
Volume25
Issue number2
Early online date11 Jun 2018
DOIs
DateAccepted/In press - 22 May 2018
DateE-pub ahead of print - 11 Jun 2018
DatePublished (current) - 1 Mar 2019

Abstract

The organisms that colonize the human body over a lifetime are diverse, extensive and gargantuan. A fair proportion of the microbiota that constitutes this human microbiome live within our oral cavities mostly as harmonious associates causing only sporadic disease. An important core constituent of the microbiome is the mycobiome, representing various fungal genera. Up until recently, only a few species of fungi, mainly Candida species, were thought to constitute the human oral mycobiome. The reasons for this are manifold, although the uncultivable nature of many fungi in conventional laboratory media, and their complex genetic composition seem to be the major factors which eluded their detection over the years. Nevertheless, recent advances in computing and high throughput sequencing such as next generation sequencing (NGS) platforms have provided us a panoramic view of a totally new world of fungi that are human oral co-habitués. Their diversity is perplexing, and functionality yet to be deciphered. Here we provide a glimpse of what is currently known of the oral mycobiome, in health and disease, with some future perspectives.

    Research areas

  • biodiversity, fungi, high‐throughput sequencing, human microbiome, oral mycobiome

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    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/abs/10.1111/odi.12899 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 228 KB, PDF document

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