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Bioinspired bactericidal surfaces with polymer nanocone arrays

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)389-399
Number of pages11
JournalJournal of Colloid and Interface Science
Volume528
Early online date28 May 2018
DOIs
DateAccepted/In press - 27 May 2018
DateE-pub ahead of print - 28 May 2018
DatePublished (current) - 15 Oct 2018

Abstract

Infections resulting from bacterial biofilm formation on the surface of medical devices are challenging to treat and can cause significant patient morbidity. Recently, it has become apparent that regulation of surface nanotopography can render surfaces bactericidal. In this study, poly(ethylene terephthalate) nanocone arrays are generated through a polystyrene nanosphere-mask colloidal lithographic process. It is shown that modification of the mask diameter leads to a direct modification of centre-to-centre spacing between nanocones. By altering the oxygen plasma etching time it is possible to modify the height, tip width and base diameter of the individual nanocone features. The bactericidal activity of the nanocone arrays was investigated against Escherichia coli and Klebsiella pneumoniae. It is shown that surfaces with the most densely populated nanocone arrays (center-to-center spacing of 200 nm), higher aspect ratios and (>3) tip widths <20 nm kill the highest percentage of bacteria (~30 %).

    Research areas

  • Bactericidal, Bioinspired, Biomaterials, Nanocone, Nanotopography

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S0021979718306179 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 2.02 MB, PDF document

    Licence: CC BY-NC-ND

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