Projects per year
Abstract
The biosynthesis of the mixed PKS-FAS-NRPS hybrid antibiotic thiomarinol A was investigated using feeding studies to both wild type and mutant strains of the marine bacterium Pseudoalteromonas. Particularly interesting features of the pathway include assembly of the 8-hydroxyoctanoic acid side-chain via chain extension of a C4-precursor (4-hydroxybutyrate), and construction of the pyrrothine unit from cysteine via (HolA-D, F-H) prior to intact incorporation into thiomarinol (catalysed by TmlU). A series of thiomarinol-related and other minor metabolites have been isolated from wild-type and mutant strains. The results of these investigations are rationalised in terms of the overall biosynthetic pathway.
Original language | English |
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Pages (from-to) | 397-402 |
Number of pages | 6 |
Journal | Chemical Science |
Volume | 5 |
Issue number | 1 |
Early online date | 1 Nov 2013 |
DOIs | |
Publication status | Published - 1 Jan 2014 |
Research Groups and Themes
- BCS and TECS CDTs
Keywords
- PSEUDOMONIC-ACID-A
- MARINE BACTERIUM
- ANTIMICROBIAL ACTIVITY
- GENE-CLUSTER
- FLUORESCENS
- ANTIBIOTICS
- MUPIROCIN
- XENORHABDUS
- HOLOMYCIN
- PATHWAY
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Dive into the research topics of 'Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390'. Together they form a unique fingerprint.Projects
- 3 Finished
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3-month Core Capability for Chemistry Research
Crosby, J. (Principal Investigator)
1/01/13 → 1/04/13
Project: Research
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BIOSYNTHESIS OF POLYKETIDE ANTIBIOTIC MUPIROCIN BY PSEUDOMONAS FLUORESCENS
Simpson, T. J. (Principal Investigator)
1/12/07 → 1/05/11
Project: Research
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PROBING DRUG RECEPTOR BINDING SITES DRIVEN BY SOLID STATE NMR-AN INTERDISCIPLINARY APPROACH
Willis, C. L. (Principal Investigator)
1/11/06 → 1/05/12
Project: Research