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Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390

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Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390. / Murphy, Annabel C.; Gao, Shu-Shan; Han, Li-Chen; Carobene, Simon; Fukuda, Daisuke; Song, Zhongshu; Hothersall, Joanne; Cox, Russell J.; Crosby, John; Crump, Matthew P.; Thomas, Christopher M.; Willis, Christine L.; Simpson, Thomas J.

In: Chemical Science, Vol. 5, No. 1, 01.01.2014, p. 397-402.

Research output: Contribution to journalArticle

Harvard

Murphy, AC, Gao, S-S, Han, L-C, Carobene, S, Fukuda, D, Song, Z, Hothersall, J, Cox, RJ, Crosby, J, Crump, MP, Thomas, CM, Willis, CL & Simpson, TJ 2014, 'Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390', Chemical Science, vol. 5, no. 1, pp. 397-402. https://doi.org/10.1039/c3sc52281d

APA

Murphy, A. C., Gao, S-S., Han, L-C., Carobene, S., Fukuda, D., Song, Z., ... Simpson, T. J. (2014). Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390. Chemical Science, 5(1), 397-402. https://doi.org/10.1039/c3sc52281d

Vancouver

Murphy AC, Gao S-S, Han L-C, Carobene S, Fukuda D, Song Z et al. Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390. Chemical Science. 2014 Jan 1;5(1):397-402. https://doi.org/10.1039/c3sc52281d

Author

Murphy, Annabel C. ; Gao, Shu-Shan ; Han, Li-Chen ; Carobene, Simon ; Fukuda, Daisuke ; Song, Zhongshu ; Hothersall, Joanne ; Cox, Russell J. ; Crosby, John ; Crump, Matthew P. ; Thomas, Christopher M. ; Willis, Christine L. ; Simpson, Thomas J. / Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390. In: Chemical Science. 2014 ; Vol. 5, No. 1. pp. 397-402.

Bibtex

@article{c157cd165f2e485ba604451940a3476b,
title = "Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390",
abstract = "The biosynthesis of the mixed PKS-FAS-NRPS hybrid antibiotic thiomarinol A was investigated using feeding studies to both wild type and mutant strains of the marine bacterium Pseudoalteromonas. Particularly interesting features of the pathway include assembly of the 8-hydroxyoctanoic acid side-chain via chain extension of a C4-precursor (4-hydroxybutyrate), and construction of the pyrrothine unit from cysteine via (HolA-D, F-H) prior to intact incorporation into thiomarinol (catalysed by TmlU). A series of thiomarinol-related and other minor metabolites have been isolated from wild-type and mutant strains. The results of these investigations are rationalised in terms of the overall biosynthetic pathway.",
keywords = "PSEUDOMONIC-ACID-A, MARINE BACTERIUM, ANTIMICROBIAL ACTIVITY, GENE-CLUSTER, FLUORESCENS, ANTIBIOTICS, MUPIROCIN, XENORHABDUS, HOLOMYCIN, PATHWAY",
author = "Murphy, {Annabel C.} and Shu-Shan Gao and Li-Chen Han and Simon Carobene and Daisuke Fukuda and Zhongshu Song and Joanne Hothersall and Cox, {Russell J.} and John Crosby and Crump, {Matthew P.} and Thomas, {Christopher M.} and Willis, {Christine L.} and Simpson, {Thomas J.}",
year = "2014",
month = "1",
day = "1",
doi = "10.1039/c3sc52281d",
language = "English",
volume = "5",
pages = "397--402",
journal = "Chemical Science",
issn = "2041-6520",
publisher = "Royal Society of Chemistry",
number = "1",

}

RIS - suitable for import to EndNote

TY - JOUR

T1 - Biosynthesis of thiomarinol A and related metabolites of Pseudoalteromonas sp SANK 73390

AU - Murphy, Annabel C.

AU - Gao, Shu-Shan

AU - Han, Li-Chen

AU - Carobene, Simon

AU - Fukuda, Daisuke

AU - Song, Zhongshu

AU - Hothersall, Joanne

AU - Cox, Russell J.

AU - Crosby, John

AU - Crump, Matthew P.

AU - Thomas, Christopher M.

AU - Willis, Christine L.

AU - Simpson, Thomas J.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - The biosynthesis of the mixed PKS-FAS-NRPS hybrid antibiotic thiomarinol A was investigated using feeding studies to both wild type and mutant strains of the marine bacterium Pseudoalteromonas. Particularly interesting features of the pathway include assembly of the 8-hydroxyoctanoic acid side-chain via chain extension of a C4-precursor (4-hydroxybutyrate), and construction of the pyrrothine unit from cysteine via (HolA-D, F-H) prior to intact incorporation into thiomarinol (catalysed by TmlU). A series of thiomarinol-related and other minor metabolites have been isolated from wild-type and mutant strains. The results of these investigations are rationalised in terms of the overall biosynthetic pathway.

AB - The biosynthesis of the mixed PKS-FAS-NRPS hybrid antibiotic thiomarinol A was investigated using feeding studies to both wild type and mutant strains of the marine bacterium Pseudoalteromonas. Particularly interesting features of the pathway include assembly of the 8-hydroxyoctanoic acid side-chain via chain extension of a C4-precursor (4-hydroxybutyrate), and construction of the pyrrothine unit from cysteine via (HolA-D, F-H) prior to intact incorporation into thiomarinol (catalysed by TmlU). A series of thiomarinol-related and other minor metabolites have been isolated from wild-type and mutant strains. The results of these investigations are rationalised in terms of the overall biosynthetic pathway.

KW - PSEUDOMONIC-ACID-A

KW - MARINE BACTERIUM

KW - ANTIMICROBIAL ACTIVITY

KW - GENE-CLUSTER

KW - FLUORESCENS

KW - ANTIBIOTICS

KW - MUPIROCIN

KW - XENORHABDUS

KW - HOLOMYCIN

KW - PATHWAY

U2 - 10.1039/c3sc52281d

DO - 10.1039/c3sc52281d

M3 - Article

VL - 5

SP - 397

EP - 402

JO - Chemical Science

JF - Chemical Science

SN - 2041-6520

IS - 1

ER -