Bleeding Diathesis in Fawn Hooded Rats: Possible Implications for Invasive Procedures and Refinement Strategies

Manon W H Schaap, Hugo van Oostrom, Saskia S Arndt, Ludo J Hellebrekers

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

The Fawn hooded (FH) rat is commonly used in biomedical research. It is widely acknowledged that the FH rat has a bleeding disorder; leading to abundant bleedings. Although this bleeding disorder is investigated to model the storage pool defect; its impact on commonly performed invasive laboratory procedures has not yet been described. Our research group experienced clinically significant consequences of this bleeding disorder following invasive procedures (including intraperitoneal injections and neurocranial surgery) in the Rjlbm: FH stock. The clinical consequences of the surgical and anesthetic protocols applied; are described including the subsequent procedural refinements applied to minimize the impact of this disorder. It is strongly recommended to take the bleeding diathesis into account when performing invasive procedures in FH rats and to apply the suggested refinement of procedures.
Original languageEnglish
Pages (from-to)270-275
Number of pages6
JournalAnimals
Volume5
Issue number2
Early online date24 Apr 2015
DOIs
Publication statusPublished - Jun 2015

Keywords

  • fawn hooded rat
  • invasive procedures
  • bleeding disorder
  • anesthesia
  • surgery
  • refinement

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