Blood type gene locus has no influence on ACE association with Alzheimer's disease

Anne Braae; Christopher Medway; Minerva Carrasquillo; Steven Younkin; Patrick G Kehoe; Kevin Morgan; Alzheimer's Research UK (ARUK) Consortium

doi:10.1016/j.neurobiolaging.2015.01.013

Blood type gene locus has no influence on ACE association with Alzheimer's disease

Anne Braae, Christopher Medway, Minerva Carrasquillo, Steven Younkin, Patrick G Kehoe, Kevin Morgan, Alzheimer's Research UK (ARUK) Consortium

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.

Original language	English
Pages (from-to)	1767.e1-2
Journal	Neurobiology of Aging
Volume	36
Issue number	4
DOIs	https://doi.org/10.1016/j.neurobiolaging.2015.01.013
Publication status	Published - Apr 2015

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title = "Blood type gene locus has no influence on ACE association with Alzheimer's disease",

abstract = "The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.",

author = "Anne Braae and Christopher Medway and Minerva Carrasquillo and Steven Younkin and Kehoe, {Patrick G} and Kevin Morgan and {Alzheimer's Research UK (ARUK) Consortium}",

year = "2015",

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doi = "10.1016/j.neurobiolaging.2015.01.013",

language = "English",

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TY - JOUR

T1 - Blood type gene locus has no influence on ACE association with Alzheimer's disease

AU - Braae, Anne

AU - Medway, Christopher

AU - Carrasquillo, Minerva

AU - Younkin, Steven

AU - Kehoe, Patrick G

AU - Morgan, Kevin

AU - Alzheimer's Research UK (ARUK) Consortium

PY - 2015/4

Y1 - 2015/4

N2 - The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.

AB - The ABO blood group locus was recently found to contribute independently and via interactions with angiotensin-converting enzyme (ACE) gene variation to plasma levels of ACE. Variation in ACE has previously been not only implicated as individually conferring susceptibility for Alzheimer's disease (AD) but also proposed to confer risk via interactions with other as yet unknown genes. More recently, larger studies have not supported ACE as a risk factor for AD, whereas the role of ACE pathway in AD has come under increased levels of scrutiny with respect to various aspects of AD pathology and possible therapies. We explored the potential combined involvement of ABO and ACE variations in the genetic susceptibility of 2067 AD cases compared with 1376 nondemented elderly. Including the effects of ABO haplotype did not provide any evidence for the genetic association of ACE with AD.

U2 - 10.1016/j.neurobiolaging.2015.01.013

DO - 10.1016/j.neurobiolaging.2015.01.013

M3 - Article (Academic Journal)

C2 - 25681990

SN - 0197-4580

VL - 36

SP - 1767.e1-2

JO - Neurobiology of Aging

JF - Neurobiology of Aging

IS - 4

ER -

Blood type gene locus has no influence on ACE association with Alzheimer's disease

Abstract

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