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BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization

Research output: Contribution to journalArticle

Original languageEnglish
Pages (from-to)1796-1806
Number of pages11
JournalObesity
Volume26
Issue number11
Early online date25 Oct 2018
DOIs
DateAccepted/In press - 15 Aug 2018
DateE-pub ahead of print - 25 Oct 2018
DatePublished (current) - Nov 2018

Abstract

Objective

The aim of this study was to obtain estimates of the causal relationship between BMI and mortality.

Methods

Mendelian randomization (MR) with BMI‐associated genotypic variation was used to test the causal effect of BMI on all‐cause and cause‐specific mortality in UK Biobank participants of White British ancestry.

Results

MR analyses supported a causal association between higher BMI and greater risk of all‐cause mortality (hazard ratio [HR] per 1 kg/m2: 1.03; 95% CI: 0.99‐1.07) and mortality from cardiovascular diseases (HR: 1.10; 95% CI: 1.01‐1.19), specifically coronary heart disease (HR: 1.12; 95% CI: 1.00‐1.25) and those excluding coronary heart disease/stroke/aortic aneurysm (HR: 1.24; 95% CI: 1.03‐1.48), stomach cancer (HR: 1.18; 95% CI: 0.87‐1.62), and esophageal cancer (HR: 1.22; 95% CI: 0.98‐1.53), and a decreased risk of lung cancer mortality (HR: 0.96; 95% CI: 0.85‐1.08). Sex stratification supported the causal role of higher BMI increasing bladder cancer mortality risk (males) but decreasing respiratory disease mortality risk (males). The J‐shaped observational association between BMI and mortality was visible with MR analyses, but the BMI at which mortality was minimized was lower and the association was flatter over a larger BMI range.

Conclusions

Results support a causal role of higher BMI in increasing the risk of all‐cause mortality and mortality from several specific causes.

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  • Full-text PDF (accepted author manuscript)

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/10.1002/oby.22313 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 562 KB, PDF document

  • Supporting Information PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/10.1002/oby.22313 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 902 KB, PDF document

  • Figure 1 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/10.1002/oby.22313 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 69 KB, PDF document

  • Figure 2 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/10.1002/oby.22313 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 71 KB, PDF document

  • Figure 3 PDF

    Rights statement: This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Wiley at https://onlinelibrary.wiley.com/doi/10.1002/oby.22313 . Please refer to any applicable terms of use of the publisher.

    Accepted author manuscript, 82 KB, PDF document

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