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BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization

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BMI and Mortality in UK Biobank : Revised Estimates Using Mendelian Randomization. / Wade, Kaitlin; Carslake, David; Sattar, Naveed; Davey Smith, George; Timpson, Nicholas.

In: Obesity, Vol. 26, No. 11, 11.2018, p. 1796-1806.

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@article{1c55a809eb2941439e1e8ac3e54e49eb,
title = "BMI and Mortality in UK Biobank: Revised Estimates Using Mendelian Randomization",
abstract = "ObjectiveThe aim of this study was to obtain estimates of the causal relationship between BMI and mortality.MethodsMendelian randomization (MR) with BMI‐associated genotypic variation was used to test the causal effect of BMI on all‐cause and cause‐specific mortality in UK Biobank participants of White British ancestry.ResultsMR analyses supported a causal association between higher BMI and greater risk of all‐cause mortality (hazard ratio [HR] per 1 kg/m2: 1.03; 95{\%} CI: 0.99‐1.07) and mortality from cardiovascular diseases (HR: 1.10; 95{\%} CI: 1.01‐1.19), specifically coronary heart disease (HR: 1.12; 95{\%} CI: 1.00‐1.25) and those excluding coronary heart disease/stroke/aortic aneurysm (HR: 1.24; 95{\%} CI: 1.03‐1.48), stomach cancer (HR: 1.18; 95{\%} CI: 0.87‐1.62), and esophageal cancer (HR: 1.22; 95{\%} CI: 0.98‐1.53), and a decreased risk of lung cancer mortality (HR: 0.96; 95{\%} CI: 0.85‐1.08). Sex stratification supported the causal role of higher BMI increasing bladder cancer mortality risk (males) but decreasing respiratory disease mortality risk (males). The J‐shaped observational association between BMI and mortality was visible with MR analyses, but the BMI at which mortality was minimized was lower and the association was flatter over a larger BMI range.ConclusionsResults support a causal role of higher BMI in increasing the risk of all‐cause mortality and mortality from several specific causes.",
author = "Kaitlin Wade and David Carslake and Naveed Sattar and {Davey Smith}, George and Nicholas Timpson",
year = "2018",
month = "11",
doi = "10.1002/oby.22313",
language = "English",
volume = "26",
pages = "1796--1806",
journal = "Obesity",
issn = "1930-7381",
publisher = "John Wiley & Sons, Inc",
number = "11",

}

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TY - JOUR

T1 - BMI and Mortality in UK Biobank

T2 - Revised Estimates Using Mendelian Randomization

AU - Wade, Kaitlin

AU - Carslake, David

AU - Sattar, Naveed

AU - Davey Smith, George

AU - Timpson, Nicholas

PY - 2018/11

Y1 - 2018/11

N2 - ObjectiveThe aim of this study was to obtain estimates of the causal relationship between BMI and mortality.MethodsMendelian randomization (MR) with BMI‐associated genotypic variation was used to test the causal effect of BMI on all‐cause and cause‐specific mortality in UK Biobank participants of White British ancestry.ResultsMR analyses supported a causal association between higher BMI and greater risk of all‐cause mortality (hazard ratio [HR] per 1 kg/m2: 1.03; 95% CI: 0.99‐1.07) and mortality from cardiovascular diseases (HR: 1.10; 95% CI: 1.01‐1.19), specifically coronary heart disease (HR: 1.12; 95% CI: 1.00‐1.25) and those excluding coronary heart disease/stroke/aortic aneurysm (HR: 1.24; 95% CI: 1.03‐1.48), stomach cancer (HR: 1.18; 95% CI: 0.87‐1.62), and esophageal cancer (HR: 1.22; 95% CI: 0.98‐1.53), and a decreased risk of lung cancer mortality (HR: 0.96; 95% CI: 0.85‐1.08). Sex stratification supported the causal role of higher BMI increasing bladder cancer mortality risk (males) but decreasing respiratory disease mortality risk (males). The J‐shaped observational association between BMI and mortality was visible with MR analyses, but the BMI at which mortality was minimized was lower and the association was flatter over a larger BMI range.ConclusionsResults support a causal role of higher BMI in increasing the risk of all‐cause mortality and mortality from several specific causes.

AB - ObjectiveThe aim of this study was to obtain estimates of the causal relationship between BMI and mortality.MethodsMendelian randomization (MR) with BMI‐associated genotypic variation was used to test the causal effect of BMI on all‐cause and cause‐specific mortality in UK Biobank participants of White British ancestry.ResultsMR analyses supported a causal association between higher BMI and greater risk of all‐cause mortality (hazard ratio [HR] per 1 kg/m2: 1.03; 95% CI: 0.99‐1.07) and mortality from cardiovascular diseases (HR: 1.10; 95% CI: 1.01‐1.19), specifically coronary heart disease (HR: 1.12; 95% CI: 1.00‐1.25) and those excluding coronary heart disease/stroke/aortic aneurysm (HR: 1.24; 95% CI: 1.03‐1.48), stomach cancer (HR: 1.18; 95% CI: 0.87‐1.62), and esophageal cancer (HR: 1.22; 95% CI: 0.98‐1.53), and a decreased risk of lung cancer mortality (HR: 0.96; 95% CI: 0.85‐1.08). Sex stratification supported the causal role of higher BMI increasing bladder cancer mortality risk (males) but decreasing respiratory disease mortality risk (males). The J‐shaped observational association between BMI and mortality was visible with MR analyses, but the BMI at which mortality was minimized was lower and the association was flatter over a larger BMI range.ConclusionsResults support a causal role of higher BMI in increasing the risk of all‐cause mortality and mortality from several specific causes.

U2 - 10.1002/oby.22313

DO - 10.1002/oby.22313

M3 - Article

VL - 26

SP - 1796

EP - 1806

JO - Obesity

JF - Obesity

SN - 1930-7381

IS - 11

ER -