Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study

Daniela Mariosa; Karl  Smith Byrne; Tom G Richardson; Pietro Ferrari; Marc J.  Gunter; Nikos Papadimitriou; Neil Murphy; Sofia Christakoudi; Konstantinos K.  Tsilidis; Elio  Riboli; David A Muller; Mark P. Purdue; Stephen J Chanock; Rayjean J. Hung; Christopher I Amos; Tracy A O'Mara; Pilar Amiano; Fabrizio  Pasanisi; Miguel Rodríguez-Barranco; Vittorio Krogh; Anne Tjønneland; Jytte Halkjær; Aurora Perez-Cornago; María-Dolores Chirlaque; Guri Skeie; Charlotta  Rylander; Kristin B Borch; Dagfinn  Aune; Alicia Heath; Heather A. Ward; Matthias B. Schulze; Catalina  Bonet; Elisabete Weiderpass; George Davey Smith; Paul Brennan; Mattias Johansson

doi:10.1093/jnci/djac061

Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study

Daniela Mariosa, Karl Smith Byrne, Tom G Richardson, Pietro Ferrari, Marc J. Gunter , Nikos Papadimitriou, Neil Murphy, Sofia Christakoudi, Konstantinos K. Tsilidis , Elio Riboli, David A Muller, Mark P. Purdue, Stephen J Chanock, Rayjean J. Hung, Christopher I Amos, Tracy A O'Mara, Pilar Amiano, Fabrizio Pasanisi, Miguel Rodríguez-Barranco, Vittorio KroghAnne Tjønneland, Jytte Halkjær, Aurora Perez-Cornago, María-Dolores Chirlaque, Guri Skeie, Charlotta Rylander, Kristin B Borch, Dagfinn Aune, Alicia Heath , Heather A. Ward, Matthias B. Schulze, Catalina Bonet, Elisabete Weiderpass, George Davey Smith, Paul Brennan^*, Mattias Johansson

^*Corresponding author for this work

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Abstract

It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23–2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09–1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.

Original language	English
Article number	djac061
Pages (from-to)	1296-1300
Number of pages	5
Journal	Journal of the National Cancer Institute
Volume	114
Issue number	9
DOIs	https://doi.org/10.1093/jnci/djac061
Publication status	Published - 19 Apr 2022

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Publisher Copyright:
© World Health Organization, 2022. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article.

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8074 (C18281/A29019) ICEP2 - Programme Award: Towards improved casual evidence and enhanced prediction of cancer risk and survival
Martin, R. M. (Principal Investigator)
1/10/20 → 30/09/25
Project: Research
IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research

Cite this

Mariosa, D., Smith Byrne, K., Richardson, T. G., Ferrari, P., Gunter , M. J., Papadimitriou, N., Murphy, N., Christakoudi, S., Tsilidis , K. K., Riboli, E., Muller, D. A., Purdue, M. P., Chanock, S. J., Hung, R. J., Amos, C. I., O'Mara, T. A., Amiano, P., Pasanisi, F., Rodríguez-Barranco, M., ... Johansson, M. (2022). Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study. Journal of the National Cancer Institute, 114(9), 1296-1300. Article djac061. https://doi.org/10.1093/jnci/djac061

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title = "Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study",

abstract = "It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23–2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09–1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.",

author = "Daniela Mariosa and {Smith Byrne}, Karl and Richardson, {Tom G} and Pietro Ferrari and Gunter, {Marc J.} and Nikos Papadimitriou and Neil Murphy and Sofia Christakoudi and Tsilidis, {Konstantinos K.} and Elio Riboli and Muller, {David A} and Purdue, {Mark P.} and Chanock, {Stephen J} and Hung, {Rayjean J.} and Amos, {Christopher I} and O'Mara, {Tracy A} and Pilar Amiano and Fabrizio Pasanisi and Miguel Rodr{\'i}guez-Barranco and Vittorio Krogh and Anne Tj{\o}nneland and Jytte Halkj{\ae}r and Aurora Perez-Cornago and Mar{\'i}a-Dolores Chirlaque and Guri Skeie and Charlotta Rylander and Borch, {Kristin B} and Dagfinn Aune and Alicia Heath and Ward, {Heather A.} and Schulze, {Matthias B.} and Catalina Bonet and Elisabete Weiderpass and {Davey Smith}, George and Paul Brennan and Mattias Johansson",

note = "Publisher Copyright: {\textcopyright} World Health Organization, 2022. All rights reserved. The World Health Organization has granted the Publisher permission for the reproduction of this article.",

year = "2022",

month = apr,

day = "19",

doi = "10.1093/jnci/djac061",

language = "English",

volume = "114",

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Mariosa, D, Smith Byrne, K, Richardson, TG, Ferrari, P, Gunter , MJ, Papadimitriou, N, Murphy, N, Christakoudi, S, Tsilidis , KK, Riboli, E, Muller, DA, Purdue, MP, Chanock, SJ, Hung, RJ, Amos, CI, O'Mara, TA, Amiano, P, Pasanisi, F, Rodríguez-Barranco, M, Krogh, V, Tjønneland, A, Halkjær, J, Perez-Cornago, A, Chirlaque, M-D, Skeie, G, Rylander, C, Borch, KB, Aune, D, Heath , A, Ward, HA, Schulze, MB, Bonet, C, Weiderpass, E, Davey Smith, G, Brennan, P & Johansson, M 2022, 'Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study', Journal of the National Cancer Institute, vol. 114, no. 9, djac061, pp. 1296-1300. https://doi.org/10.1093/jnci/djac061

TY - JOUR

T1 - Body Size at Different Ages and Risk of 6 Cancers

T2 - A Mendelian Randomization and Prospective Cohort Study

AU - Mariosa, Daniela

AU - Smith Byrne, Karl

AU - Richardson, Tom G

AU - Ferrari, Pietro

AU - Gunter , Marc J.

AU - Papadimitriou, Nikos

AU - Murphy, Neil

AU - Christakoudi, Sofia

AU - Tsilidis , Konstantinos K.

AU - Riboli, Elio

AU - Muller, David A

AU - Purdue, Mark P.

AU - Chanock, Stephen J

AU - Hung, Rayjean J.

AU - Amos, Christopher I

AU - O'Mara, Tracy A

AU - Amiano, Pilar

AU - Pasanisi, Fabrizio

AU - Rodríguez-Barranco, Miguel

AU - Krogh, Vittorio

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - Perez-Cornago, Aurora

AU - Chirlaque, María-Dolores

AU - Skeie, Guri

AU - Rylander, Charlotta

AU - Borch, Kristin B

AU - Aune, Dagfinn

AU - Heath , Alicia

AU - Ward, Heather A.

AU - Schulze, Matthias B.

AU - Bonet, Catalina

AU - Weiderpass, Elisabete

AU - Davey Smith, George

AU - Brennan, Paul

AU - Johansson, Mattias

PY - 2022/4/19

Y1 - 2022/4/19

N2 - It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23–2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09–1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.

AB - It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for six obesity-related cancers, we performed univariable and multivariable analyses using i) Mendelian randomization (MR) analysis and ii) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger body size at age 10 was associated with higher risk of endometrial (ORMR=1.61, 95%CI = 1.23–2.11) and kidney cancer (ORMR=1.40, 95%CI = 1.09–1.80). These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life BMI was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.

U2 - 10.1093/jnci/djac061

DO - 10.1093/jnci/djac061

M3 - Article (Academic Journal)

C2 - 35438160

SN - 0027-8874

VL - 114

SP - 1296

EP - 1300

JO - Journal of the National Cancer Institute

JF - Journal of the National Cancer Institute

IS - 9

M1 - djac061

ER -

Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study

Abstract

Bibliographical note

Research Groups and Themes

UN SDGs

Access to Document

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Projects

8074 (C18281/A29019) ICEP2 - Programme Award: Towards improved casual evidence and enhanced prediction of cancer risk and survival

IEU: MRC Integrative Epidemiology Unit Quinquennial renewal

Cite this