Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications

Andrew M. Collins, Nick J. V. Skaer, Tom Cheysens, David Knight, Caroline Bertram, Helmtrud I. Roach, Richard O. C. Oreffo, Sonja Von-Aulock, Teodoro Baris, John Skinner, Stephen Mann*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

62 Citations (Scopus)

Abstract

Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.

Original languageEnglish
Pages (from-to)75-78
Number of pages4
JournalAdvanced Materials
Volume21
Issue number1
DOIs
Publication statusPublished - 5 Jan 2009

Keywords

  • MESENCHYMAL STEM-CELLS
  • IN-VITRO
  • FIBROIN
  • BIOMATERIALS
  • COLLAGEN
  • DEFECTS
  • DELIVERY
  • APATITE
  • SPIDER
  • FILMS

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