Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications

Andrew M. Collins; Nick J. V. Skaer; Tom Cheysens; David Knight; Caroline Bertram; Helmtrud I. Roach; Richard O. C. Oreffo; Sonja Von-Aulock; Teodoro Baris; John Skinner; Stephen Mann

doi:10.1002/adma.200802239

Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications

Andrew M. Collins, Nick J. V. Skaer, Tom Cheysens, David Knight, Caroline Bertram, Helmtrud I. Roach, Richard O. C. Oreffo, Sonja Von-Aulock, Teodoro Baris, John Skinner, Stephen Mann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

62 Citations (Scopus)

Abstract

Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.

Original language	English
Pages (from-to)	75-78
Number of pages	4
Journal	Advanced Materials
Volume	21
Issue number	1
DOIs	https://doi.org/10.1002/adma.200802239
Publication status	Published - 5 Jan 2009

Keywords

MESENCHYMAL STEM-CELLS
IN-VITRO
FIBROIN
BIOMATERIALS
COLLAGEN
DEFECTS
DELIVERY
APATITE
SPIDER
FILMS

Access to Document

10.1002/adma.200802239

Cite this

@article{ae575af1cd744e75b902eb1088f90312,

title = "Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications",

abstract = "Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.",

keywords = "MESENCHYMAL STEM-CELLS, IN-VITRO, FIBROIN, BIOMATERIALS, COLLAGEN, DEFECTS, DELIVERY, APATITE, SPIDER, FILMS",

author = "Collins, {Andrew M.} and Skaer, {Nick J. V.} and Tom Cheysens and David Knight and Caroline Bertram and Roach, {Helmtrud I.} and Oreffo, {Richard O. C.} and Sonja Von-Aulock and Teodoro Baris and John Skinner and Stephen Mann",

year = "2009",

month = jan,

day = "5",

doi = "10.1002/adma.200802239",

language = "English",

volume = "21",

pages = "75--78",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley",

number = "1",

}

Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications. / Collins, Andrew M.; Skaer, Nick J. V.; Cheysens, Tom; Knight, David; Bertram, Caroline; Roach, Helmtrud I.; Oreffo, Richard O. C.; Von-Aulock, Sonja; Baris, Teodoro; Skinner, John; Mann, Stephen.

In: Advanced Materials, Vol. 21, No. 1, 05.01.2009, p. 75-78.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications

AU - Collins, Andrew M.

AU - Skaer, Nick J. V.

AU - Cheysens, Tom

AU - Knight, David

AU - Bertram, Caroline

AU - Roach, Helmtrud I.

AU - Oreffo, Richard O. C.

AU - Von-Aulock, Sonja

AU - Baris, Teodoro

AU - Skinner, John

AU - Mann, Stephen

PY - 2009/1/5

Y1 - 2009/1/5

N2 - Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.

AB - Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.

KW - MESENCHYMAL STEM-CELLS

KW - IN-VITRO

KW - FIBROIN

KW - BIOMATERIALS

KW - COLLAGEN

KW - DEFECTS

KW - DELIVERY

KW - APATITE

KW - SPIDER

KW - FILMS

U2 - 10.1002/adma.200802239

DO - 10.1002/adma.200802239

M3 - Article (Academic Journal)

VL - 21

SP - 75

EP - 78

JO - Advanced Materials

JF - Advanced Materials

SN - 0935-9648

IS - 1

ER -