Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications

Andrew M. Collins; Nick J. V. Skaer; Tom Cheysens; David Knight; Caroline Bertram; Helmtrud I. Roach; Richard O. C. Oreffo; Sonja Von-Aulock; Teodoro Baris; John Skinner; Stephen Mann

doi:10.1002/adma.200802239

Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications

Andrew M. Collins
, Nick J. V. Skaer
, Tom Cheysens
, David Knight
, Caroline Bertram
, Helmtrud I. Roach
, Richard O. C. Oreffo
, Sonja Von-Aulock
, Teodoro Baris
, John Skinner
, Stephen Mann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

88 Citations (Scopus)

Abstract

Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.

Original language	English
Pages (from-to)	75-78
Number of pages	4
Journal	Advanced Materials
Volume	21
Issue number	1
DOIs	https://doi.org/10.1002/adma.200802239
Publication status	Published - 5 Jan 2009

Research Groups and Themes

Inorganic & Materials

Keywords

MESENCHYMAL STEM-CELLS
IN-VITRO
FIBROIN
BIOMATERIALS
COLLAGEN
DEFECTS
DELIVERY
APATITE
SPIDER
FILMS

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@article{ae575af1cd744e75b902eb1088f90312,

title = "Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications",

abstract = "Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.",

keywords = "MESENCHYMAL STEM-CELLS, IN-VITRO, FIBROIN, BIOMATERIALS, COLLAGEN, DEFECTS, DELIVERY, APATITE, SPIDER, FILMS",

author = "Collins, \{Andrew M.\} and Skaer, \{Nick J. V.\} and Tom Cheysens and David Knight and Caroline Bertram and Roach, \{Helmtrud I.\} and Oreffo, \{Richard O. C.\} and Sonja Von-Aulock and Teodoro Baris and John Skinner and Stephen Mann",

year = "2009",

month = jan,

day = "5",

doi = "10.1002/adma.200802239",

language = "English",

volume = "21",

pages = "75--78",

journal = "Advanced Materials",

issn = "0935-9648",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications

AU - Collins, Andrew M.

AU - Skaer, Nick J. V.

AU - Cheysens, Tom

AU - Knight, David

AU - Bertram, Caroline

AU - Roach, Helmtrud I.

AU - Oreffo, Richard O. C.

AU - Von-Aulock, Sonja

AU - Baris, Teodoro

AU - Skinner, John

AU - Mann, Stephen

PY - 2009/1/5

Y1 - 2009/1/5

N2 - Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.

AB - Hydroxyapatite/silk biocompatible composites with unprecedented mechanical strength and toughness areproduced in a new process with theintegrated mineralization of macroporous silk fibroin scaffolds. Thebiomimetic bone-like composites areabsorbable and load-bearing with compressive strength, modulus, andtoughness comparable to the mechanical tolerances of cancellous bone.

KW - MESENCHYMAL STEM-CELLS

KW - IN-VITRO

KW - FIBROIN

KW - BIOMATERIALS

KW - COLLAGEN

KW - DEFECTS

KW - DELIVERY

KW - APATITE

KW - SPIDER

KW - FILMS

U2 - 10.1002/adma.200802239

DO - 10.1002/adma.200802239

M3 - Article (Academic Journal)

SN - 0935-9648

VL - 21

SP - 75

EP - 78

JO - Advanced Materials

JF - Advanced Materials

IS - 1

ER -

Bone-like Resorbable Silk-based Scaffolds for Load-bearing Osteoregenerative Applications

Abstract

Research Groups and Themes

Keywords

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