Brain biopsy in benign neurological disease

CE Gilkes, S Love, R Hardie, RJ Edwards, N Scolding, CM Rice

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)


Brain biopsy is well established in clinical practice when there is suspicion of CNS malignancy. However, there is little consensus regarding the indications for brain biopsy in non-malignant neurological disease. This is due in no small part to limitations in the available literature pertaining to diagnostic brain biopsies. The published evidence largely comprises small, retrospective, single-centre analyses performed over long time periods, including non-homogeneous patient groups with considerable variation in reported outcomes. Here we present pragmatic guidance for those clinicians considering diagnostic brain biopsy in a patient with non-neoplastic neurological disease and highlight practice points with the aim of maximising the probability of gaining clinically useful information from the procedure.
Translated title of the contributionBrain biopsy in benign neurological disease
Original languageEnglish
Pages (from-to)995-1000
JournalJournal of Neurology
Issue number5
Publication statusPublished - Feb 2012

Structured keywords

  • Dementia Research Group


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