TY - JOUR
T1 - Brain mechanisms of altered consciousness in generalised seizures
AU - Seri, Stefano
AU - Brazzo, Daniela
AU - Thai, Ngoc J
AU - Cerquiglini, Antonella
PY - 2011
Y1 - 2011
N2 - In spite of the inherent difficulties in achieving a biologically meaningful definition of consciousness, recent neurophysiological studies are starting to provide some insight in fundamental mechanisms associated with impaired consciousness in neurological disorders. Generalised seizures are associated with disruption of the default state network, a functional network of discrete brain areas, which include the fronto-parietal cortices. Subcortical contribution through activation of thalamocortical structures, as well as striate nuclei are also crucial to produce impaired consciousness in generalised seizures.
AB - In spite of the inherent difficulties in achieving a biologically meaningful definition of consciousness, recent neurophysiological studies are starting to provide some insight in fundamental mechanisms associated with impaired consciousness in neurological disorders. Generalised seizures are associated with disruption of the default state network, a functional network of discrete brain areas, which include the fronto-parietal cortices. Subcortical contribution through activation of thalamocortical structures, as well as striate nuclei are also crucial to produce impaired consciousness in generalised seizures.
U2 - 10.3233/BEN-2011-0317
DO - 10.3233/BEN-2011-0317
M3 - Article (Academic Journal)
C2 - 21447897
VL - 24
SP - 43
EP - 46
JO - Behavioural Neurology
JF - Behavioural Neurology
SN - 0953-4180
IS - 1
ER -