Brain mechanisms of altered consciousness in generalised seizures

Stefano Seri, Daniela Brazzo, Ngoc J Thai, Antonella Cerquiglini

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)


In spite of the inherent difficulties in achieving a biologically meaningful definition of consciousness, recent neurophysiological studies are starting to provide some insight in fundamental mechanisms associated with impaired consciousness in neurological disorders. Generalised seizures are associated with disruption of the default state network, a functional network of discrete brain areas, which include the fronto-parietal cortices. Subcortical contribution through activation of thalamocortical structures, as well as striate nuclei are also crucial to produce impaired consciousness in generalised seizures.
Original languageEnglish
Pages (from-to)43-6
Number of pages4
JournalBehavioural Neurology
Issue number1
Publication statusPublished - 2011


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