Brainstem respiratory networks: building blocks and microcircuits

Jeffrey C Smith, Ana Paula Abdala Sheikh, Anke Borgmann, Ilya A Rybak, Julian F R Paton

Research output: Contribution to journalArticle (Academic Journal)peer-review

205 Citations (Scopus)


Breathing movements in mammals are driven by rhythmic neural activity generated within spatially and functionally organized brainstem neural circuits comprising the respiratory central pattern generator (CPG). This rhythmic activity provides homeostatic regulation of gases in blood and tissues and integrates breathing with other motor acts. We review new insights into the spatial-functional organization of key neural microcircuits of this CPG from recent multidisciplinary experimental and computational studies. The emerging view is that the microcircuit organization within the CPG allows the generation of multiple rhythmic breathing patterns and adaptive switching between them, depending on physiological or pathophysiological conditions. These insights open the possibility for site- and mechanism-specific interventions to treat various disorders of the neural control of breathing.
Original languageEnglish
Pages (from-to)152-62
Number of pages11
JournalTrends in Neurosciences
Issue number3
Publication statusPublished - Mar 2013

Bibliographical note

Published by Elsevier Ltd.

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