Branch-Selective Alkene Hydroarylation by Cooperative Destabilization: Iridium-Catalyzed ortho-Alkylation of Acetanilides

Giacomo Crisenza, Sokolova, Olga O., John Bower

Research output: Contribution to journalArticle (Academic Journal)

44 Citations (Scopus)
1 Downloads (Pure)

Abstract

An iridium(I) catalyst system, modified with the wide-bite-angle and electron-deficient bisphosphine dFppb (1,4-bis(di(pentafluorophenyl)phosphino)butane) promotes highly branch-selective hydroarylation reactions between diverse acetanilides and aryl- or alkyl-substituted alkenes. This provides direct and ortho-selective access to synthetically challenging anilines, and addresses long-standing issues associated with related Friedel–Crafts alkylations.
Original languageEnglish
Pages (from-to)14866-14870
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number49
Early online date22 Oct 2015
DOIs
Publication statusPublished - 1 Dec 2015

Structured keywords

  • BCS and TECS CDTs

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